Back to Search
Start Over
C–H alkenylation/cyclization and sulfamidation of 2-phenylisatogens using N-oxide as a directing group
- Source :
- Chemical Communications. 55:10623-10626
- Publication Year :
- 2019
- Publisher :
- Royal Society of Chemistry (RSC), 2019.
-
Abstract
- The first example of transition-metal-catalyzed C-H activations of 2-phenylisatogens with alkynes and sulfonyl azides has been developed using N-oxide as the directing group. Ru(ii)-Catalyzed C-H alkenylation/cyclization and Ir(iii)-catalyzed direct C-H sulfamidation proceeded with good yields and excellent functional group tolerance. Importantly, these two transformations provided straightforward routes for the synthesis of indol-3-one derivatives and sulfamidated 2-phenylisatogens respectively, which might be of considerable bioactivities.
- Subjects :
- Sulfonyl
chemistry.chemical_classification
010405 organic chemistry
Chemistry
Metals and Alloys
Oxide
General Chemistry
010402 general chemistry
01 natural sciences
Medicinal chemistry
Catalysis
0104 chemical sciences
Surfaces, Coatings and Films
Electronic, Optical and Magnetic Materials
chemistry.chemical_compound
Group (periodic table)
Functional group
Materials Chemistry
Ceramics and Composites
Subjects
Details
- ISSN :
- 1364548X and 13597345
- Volume :
- 55
- Database :
- OpenAIRE
- Journal :
- Chemical Communications
- Accession number :
- edsair.doi.dedup.....4988ed7b6ab5acb159f80dcfaf3767c0