Search

Your search keyword '"Robert Pal"' showing total 3 results
Start Over Author "Robert Pal" Journal chemical communications
3 results on '"Robert Pal"'

1. Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes

Author

Brian K. McMahon, Robert Pal, David Parker, and David G. Smith

Subjects
Lanthanide probes, Inorganic chemistry, chemistry.chemical_element, Terbium, CHO Cells, 010402 general chemistry, Ph changes, Lanthanoid Series Elements, 01 natural sciences, Catalysis, Cell Line, Mice, Cricetulus, Europium, Coordination Complexes, Live cell imaging, Cricetinae, Materials Chemistry, Animals, Humans, skin and connective tissue diseases, Fluorescent Dyes, 010405 organic chemistry, Metals and Alloys, General Chemistry, Hydrogen-Ion Concentration, Intensity ratio, Fluorescence, 0104 chemical sciences, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, chemistry, MCF-7 Cells, NIH 3T3 Cells, Ceramics and Composites, Biophysics, sense organs, Lysosomes, HeLa Cells
Abstract

Europium and terbium complexes of two structurally related ligands have been evaluated as optical probes to monitor changes in lysosomal pH; calibration using ionophores and fluorescent probes allows monitoring of the time dependence of lysosomal pH change, examining the green/red intensity ratio from internalised Tb-Eu complexes.

Published
2012
Full Text
View/download PDF

2. Responsive and reactive terbium complexes with an azaxanthone sensitiser and one naphthyl group: applications in ratiometric oxygen sensing in vitro and in regioselective cell killing

Author

Ga Lai Law, David Parker, Ka-Leung Wong, Lars O. Palsson, and Robert Pal

Subjects
Xanthones, chemistry.chemical_element, Apoptosis, Terbium, Naphthols, Photochemistry, Catalysis, Mice, Structure-Activity Relationship, chemistry.chemical_compound, Materials Chemistry, Animals, Oxygen sensing, Aza Compounds, Molecular Structure, Singlet oxygen, Metals and Alloys, Regioselectivity, General Chemistry, In vitro, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, Oxygen, Cell killing, chemistry, NIH 3T3 Cells, Ceramics and Composites
Abstract

A terbium complex has been designed that may be used to sensitise formation of singlet oxygen (phi(em) 12%), allowing the creation of a ratiometric sensory system for pO(2) (versus the insensitive Eu analogue) and the definition of a reactive probe that can be used to cause local damage to cells loaded with the complex and exposed to laser excitation.

Published
2009
Full Text
View/download PDF

3. A single component ratiometric pH probe with long wavelength excitation of europium emission.

Author

Robert Pal and David Parker

Subjects
*EUROPIUM, *MACROCYCLIC compounds, *SPECTRUM analysis, *MACROMOLECULES
Abstract

Following excitation in the range 370–405 nm, the emission spectrum of a cell permeable macrocyclic Eu(iii) complex incorporating an N-methylsulfonamide moiety changes form with pH, allowing ratiometric pH measurements in the range 6 to 8. [ABSTRACT FROM AUTHOR]

Published
2007
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results