Live cell imaging of lysosomal pH changes with pH responsive ratiometric lanthanide probes

Authors :: Brian K. McMahon
Robert Pal
David Parker
David G. Smith
Source :: Chemical Communications. 48:8520
Publication Year :: 2012
Publisher :: Royal Society of Chemistry (RSC), 2012.
Abstract: Europium and terbium complexes of two structurally related ligands have been evaluated as optical probes to monitor changes in lysosomal pH; calibration using ionophores and fluorescent probes allows monitoring of the time dependence of lysosomal pH change, examining the green/red intensity ratio from internalised Tb-Eu complexes.

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