1. Neolamarckines A and B, New Indole Alkaloids from Neolamarckia cadamba
- Author
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Khalit Mohamad, Khalijah Awang, Takahiro Hosoya, Osamu Shirota, Ahmad Kaleem Qureshi, Mat Ropi Mukhtar, Alfarius Eko Nugroho, Hiroshi Morita, A. Hamid A. Hadi, Marc Litaudon, and Yusuke Hirasawa
- Subjects
Indole test ,Circular dichroism ,Rubiaceae ,food.ingredient ,biology ,Chemistry ,Stereochemistry ,Neolamarckia ,General Chemistry ,General Medicine ,biology.organism_classification ,Nitric oxide synthase ,food ,Drug Discovery ,biology.protein - Abstract
Two new indole alkaloids, neolamarckines A and B (1, 2) were isolated from the leaves of Neolamarckia cadamba (Rubiaceae). Structural elucidation of 1 and 2 was performed by combination of 2D-NMR and circular dichroism (CD) spectra, and chemical correlations. Neolamarckine A (1) showed inhibition of inducible nitric oxide synthase (iNOS) dose dependently.
- Published
- 2011
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