Neolamarckines A and B, New Indole Alkaloids from Neolamarckia cadamba

Authors :: Khalit Mohamad
Khalijah Awang
Takahiro Hosoya
Osamu Shirota
Ahmad Kaleem Qureshi
Mat Ropi Mukhtar
Alfarius Eko Nugroho
Hiroshi Morita
A. Hamid A. Hadi
Marc Litaudon
Yusuke Hirasawa
Source :: CHEMICAL & PHARMACEUTICAL BULLETIN. 59:291-293
Publication Year :: 2011
Publisher :: Pharmaceutical Society of Japan, 2011.
Abstract: Two new indole alkaloids, neolamarckines A and B (1, 2) were isolated from the leaves of Neolamarckia cadamba (Rubiaceae). Structural elucidation of 1 and 2 was performed by combination of 2D-NMR and circular dichroism (CD) spectra, and chemical correlations. Neolamarckine A (1) showed inhibition of inducible nitric oxide synthase (iNOS) dose dependently.