1. A Case of Neurotrophic Keratopathy Associated with Nasopharyngeal Carcinoma
- Author
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Koji Sugioka, Yoshikazu Shimomura, Masahiko Fukuda, Tomoko Sato, Hiroshi Mishima, and Aya Kodama-Takahashi
- Subjects
Pathology ,medicine.medical_specialty ,genetic structures ,Neurotrophic keratopathy ,medicine.medical_treatment ,Case Report ,Metastasis ,03 medical and health sciences ,0302 clinical medicine ,lcsh:Ophthalmology ,Nasopharyngeal carcinoma ,otorhinolaryngologic diseases ,Medicine ,Cavernous sinus ,Corneal stromal edema ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,medicine.disease ,eye diseases ,Transplantation ,Ophthalmology ,Artificial tears ,lcsh:RE1-994 ,030221 ophthalmology & optometry ,sense organs ,business ,030217 neurology & neurosurgery - Abstract
Purpose: To report a case of neurotrophic keratopathy associated with nasopharyngeal carcinoma. Case Report: A 59-year-old man who had been diagnosed with a nasopharyngeal carcinoma was referred to the authors because of visual disturbance and pain in his right eye. Slit-lamp examination revealed a corneal epithelial defect and corneal stromal edema surrounding the epithelial defect area in his right eye. Magnetic resonance imaging showed a mass in his cavernous sinus, which was identified as nasopharyngeal carcinoma (NPC). We diagnosed neurotrophic keratopathy associated with NPC and initiated treatment with preservative-free artificial tears, antibiotic eye drops, fibronectin, a therapeutic contact lens, and amniotic membrane transplantation. However, the persistent corneal epithelial defect was unresponsive to these treatments. Conclusion: Neurotrophic keratopathy secondary to NPC is thought to be rare. We presented a case of neurotrophic keratopathy associated with cavernous sinus metastasis of an NPC. The development of new and more effective treatments for this refractory disease is anticipated.
- Published
- 2018