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A recent study conducted at Manisa Celal Bayar University in Turkey focused on the prognostic significance of the Positive Lymph Node Ratio (PLNR) score in elderly patients with surgically treated gastric cancer. The research found that patients with a PLNR score above 0.138 had a significantly lower median overall survival compared to those below this threshold. While the PLNR system emerged as an independent predictor of survival and recurrence, it was noted that it should be used as a supplementary tool in predicting prognosis, especially in elderly patients unsuitable for standard lymph node dissection. [Extracted from the article]

A recent study conducted at Shandong University in China examined the impact of surgeons' annual volume and IGFL2 expression on gastric cancer prognosis. The research found that high IGFL2 expression and low surgical volume were independent predictors of poorer overall survival and disease-free survival. Surgeons performing more than 26 cases annually had higher survival rates, and nomograms integrating various factors showed superior predictive accuracy for patient outcomes. This study highlights the importance of specialized training and further research on IGFL2's molecular mechanisms to enhance gastric cancer patient outcomes. [Extracted from the article]

A recent study from the University of South China explores the role of Angiopoietin-like protein 4 (ANGPTL4) in gastric cancer, revealing its impact on processes such as proliferation, migration, and angiogenesis. The research highlights the paradoxical effects of ANGPTL4 in different gastric cancer cell lines, with findings suggesting that ANGPTL4 may influence cancer progression through the LGALS7 and Hedgehog pathways. This study sheds light on the complex mechanisms underlying gastric cancer development and offers insights into potential therapeutic targets. [Extracted from the article]

Researchers at the First Affiliated Hospital of Wenzhou Medical University in China have published a study on gastric cancer, highlighting the potential of affibody molecules for tumor-targeting and molecular imaging diagnosis in gastrointestinal cancer. The study focuses on the use of affibodies specific to the carcinoembryonic antigen (CEA) protein, showing promising results in targeting CEA+ xenograft-bearing mice. This research suggests the potential use of ZCEA affibodies as fluorescent molecular imaging probes for detecting CEA expression in gastrointestinal cancer. [Extracted from the article]

A recent study conducted at Beijing University of Chinese Medicine focused on the use of gastric filling ultrasonography (GFUS) for the diagnosis of infiltration depth in gastric carcinoma. The research highlighted the effectiveness of GFUS in identifying different stages of gastric cancer, particularly for advanced stages. The study emphasized the importance of early detection and precise evaluation of infiltration depth in gastric carcinoma for determining appropriate treatment approaches and improving patient outcomes. Researchers suggested further standardization of ultrasonographic techniques and integration of GFUS with other diagnostic methods to enhance its clinical utility. [Extracted from the article]

Researchers from the University of Crete have conducted a study on gastrointestinal (GI) cancers, focusing on gastric cancer. The study highlights the importance of telomere length (TL) and telomerase activity (TA) as potential biomarkers for diagnosing, prognosticating, and predicting GI cancers. By examining the role of TL and TA in GI tumors, the research aims to enhance early detection, treatment, and prognosis of these cancers. The study emphasizes the critical need for new biomarkers and therapeutic targets in addressing the global health challenges posed by GI cancers. [Extracted from the article]

A recent study conducted at Zhongnan Hospital of Wuhan University focused on the relationship between gastric adenocarcinoma and depressive disorder. Researchers identified 56 hub genes related to both conditions and developed a prognostic signature based on these genes. The study found that patients with a higher risk score had worse overall survival and identified potential therapy candidates for gastric adenocarcinoma patients. This research provides valuable insights into the molecular and immune characteristics of gastric cancer and its correlation with depressive risk. [Extracted from the article]

Researchers at Fudan University conducted a study on gastric cancer, specifically focusing on CDH1 mutations and their implications for treatment. The study found that CDH1 mutations are associated with poor prognosis in gastric cancer patients and may benefit from targeted therapies such as PARP and Wee1 inhibitors. The research highlighted the distinct genomic landscape of CDH1-mutated gastric cancer and emphasized the potential for personalized treatment strategies based on these findings. The study was published in npj Precision Oncology and can be accessed for further information. [Extracted from the article]

A recent study conducted at Royal North Shore Hospital in Sydney, Australia, focused on the efficacy of regorafenib in treating refractory advanced gastric cancer. The research found that regorafenib improved overall survival compared to a placebo, with a median survival of 4.5 months versus 4.0 months and 12-month survival rates of 19% and 6%, respectively. The study also showed that regorafenib improved progression-free survival and delayed deterioration in quality of life for participants. This study provides valuable insights into potential treatment options for patients with advanced gastric cancer. [Extracted from the article]

A recent report published in Cancer Weekly discusses the significance of stromal cell derived factor 2 (SDF2) in gastric cancer (GC) patients. The study found that SDF2 expression was higher in GC tissue compared to normal gastric tissue. Additionally, SDF2 expression was associated with certain clinicopathological characteristics and prognosis of GC patients, such as Borrmann classification III-IV, tumor infiltration depth, positive lymph node metastasis, and TNM III-IV stage. The study concluded that GC patients with high SDF2 expression had significantly poorer overall survival. Further research is needed to explore the potential implications of SDF2 in the diagnosis and treatment of gastric cancer. [Extracted from the article]

A recent study conducted by researchers at the Medical University of Lodz in Poland analyzed the expression of IKK complex genes in selected gastrointestinal cancers using bioinformatics. The study found that the genes IKBKB and IKBKG were significantly upregulated in all examined cancers, while CHUK was upregulated in esophageal carcinoma and stomach adenocarcinoma. The expression of these genes also varied with histological grade and nodal metastases. The researchers suggest that these genes could serve as prognostic markers and therapeutic targets for gastrointestinal cancers. [Extracted from the article]

A recent study from Oita University in Japan explores the challenges of eradicating Helicobacter pylori (H. pylori), a bacterium associated with gastric cancer, chronic gastritis, peptic ulcers, and MALT lymphoma. The study highlights the decreasing efficacy of conventional antibiotic therapy due to antimicrobial resistance and biofilm formation. The researchers suggest alternative approaches such as targeting biofilm, repurposing outer membrane vesicles, phage therapy, probiotics, and the use of nanoparticles. This review provides valuable insights into potential strategies to counteract H. pylori resistance and improve treatment outcomes. [Extracted from the article]

A recent study conducted at the University of Texas MD Anderson Cancer Center examined the effectiveness of palliative interventions in advanced gastric cancer. The study found that less than 25% of gastric cancers are discovered early, leading to limited treatment options and poor outcomes. The researchers conducted a literature review and found that palliative gastrectomy (PG) showed improved overall survival (OS) only with adjuvant chemotherapy in a selective population, while surgical bypass (SB) had lower mortality rates compared to PG. The study concluded that further research is needed to explore correlations and that operative intervention without systemic chemotherapy is unlikely to demonstrate a survival benefit. [Extracted from the article]

A recent study conducted in Ningbo, China, aimed to develop a preoperative predictive model (PPM) for assessing the lymph node metastasis (LNM) status in patients with gastric cancer (GC). The study analyzed data from consecutive GC patients and identified risk factors associated with LNM, including cT3 invasion, CT-reported LN (+), and CA199 value. The PPM was found to be more effective in diagnosing LNM than CT-reported LN status alone. This research provides valuable insights into improving the preoperative assessment of LNM in GC patients. [Extracted from the article]

A recent report from researchers at Tianjin Medical University Cancer Institute and Hospital in China discusses the role of Secretory carrier-associated membrane protein 1 (SCAMP1) in gastric cancer. The study found that SCAMP1 expression was increased in gastric cancer tissues and correlated with tumor size and lymph node metastasis. Knockdown of SCAMP1 suppressed the proliferation of gastric cancer cells and altered the expression profile of these cells, particularly affecting receptor tyrosine kinases and their related downstream signaling pathways. The study suggests that further investigation into SCAMP1 could have potential implications for treating gastric cancer. [Extracted from the article]

Researchers from Zhejiang University School of Medicine conducted a study to investigate the molecular mechanisms of malnutrition in patients with gastric cancer. They used non-targeted metabolomics to analyze serum samples from malnourished and non-malnourished patients with gastric cancer. The study identified specific differential metabolites and matched them with corresponding metabolic pathways. A predictive model was developed based on four annotated significantly differential metabolites. These findings contribute to a better understanding of malnutrition in gastric cancer patients and may lead to new strategies for prediction, diagnosis, prevention, and treatment of malnutrition in this population. [Extracted from the article]

Debbie's Dream Foundation: Curing Stomach Cancer (DDF) has opened registration for its 13th Annual Stomach Cancer Capitol Hill Advocacy Day, which will take place from February 23-25, 2025 in Washington, DC. The event provides an opportunity for advocates, patients, survivors, caregivers, healthcare providers, and researchers to meet with lawmakers and advocate for increased funding for stomach cancer research. The foundation's advocacy efforts have already resulted in legislative wins, including securing a provision in the Senate's FY2025 National Defense Authorization Act. DDF encourages anyone impacted by stomach cancer to join them on Capitol Hill to advocate for increased research funding and policy change. [Extracted from the article]

A recent study conducted by researchers at Kermanshah University of Medical Sciences aimed to estimate the global prevalence of gastric intestinal metaplasia (GIM), a precancerous lesion that increases the risk of gastric cancer. The study analyzed 20 articles with a sample size of 57,263 and found that the global prevalence of GIM was 17.5%. The highest prevalence was observed in the American continent and among patients with gastroesophageal reflux. The researchers concluded that further investigation and attention from experts, officials, and health policymakers is needed. [Extracted from the article]

A recent report from the University of Central Punjab discusses the use of computer-aided diagnosis (CAD) systems in analyzing digital histopathology images for detecting gastric cancer (GC). The researchers propose a novel framework for gastric histology classification and segmentation (GHCS) that shows modest improvements over existing CAD models. The framework utilizes a Naive Bayes classifier and an improved Fuzzy c-means method for classification and segmentation tasks, respectively. The study demonstrates high classification accuracies and good results in picture segmentation, and the model's interpretability is enhanced through visualizations. This research contributes to the field of gastric cancer detection and may lead to better results across various datasets. [Extracted from the article]

A new study from the University Clinical Hospital in Lublin, Poland explores the relationship between oral microbiota and gastrointestinal cancers. The study highlights the impact of imbalances in oral bacteria on the development of various cancers, including oral, esophageal, gastric, colorectal, hepatocellular, and pancreatic cancers. The researchers identify potential oncogenic mechanisms, such as the production of pro-inflammatory cytokines and disruption of cell metabolic pathways. The study concludes that further research on the oral microbiota's role in gastrointestinal cancers could contribute to their prevention, diagnosis, and treatment in the future. [Extracted from the article]

A recent study conducted by researchers at the National Cancer Center focused on a case of gastric cancer. The study involved a 70-year-old woman who had previously undergone distal gastrectomy for gastric adenocarcinoma. After six years, a follow-up CT scan revealed a suspicious mass in the lung, initially thought to be mediastinal lymph nodes. However, further examination using dynamic PET/CT imaging showed that the mass was actually a second primary cancer in the bronchus. The study highlights the importance of using 18F-FDG PET/CT in the follow-up of patients with a history of tumors, and suggests that dynamic quantification parameters like Ki can be helpful in identifying malignancies in certain situations. [Extracted from the article]

A study conducted at Zhongshan City People's Hospital in Guangdong, China, explored the role of long intergenic noncoding RNA for IGF2BP2 stability (LINRIS) in gastric cancer (GC). The researchers found that LINRIS was overexpressed in GC and negatively correlated with mature microRNA-34a (miR-34a). Silencing LINRIS and overexpressing miR-34a promoted cell apoptosis and inhibited cell migration and invasion in GC cells. The study suggests that silencing LINRIS in GC may promote cell apoptosis by enhancing miR-34a maturation. Further research is needed to fully understand the potential therapeutic implications of these findings. [Extracted from the article]

A recent study published in Cancer Weekly explores the role of the m6A reader protein IGF2BP3 in gastric cancer. The study found that IGF2BP3 is significantly upregulated in gastric cancer tissues and is associated with lymph node metastasis and advanced stages of the disease. In vitro and in vivo experiments demonstrated that IGF2BP3 promotes the growth, migration, and invasion of gastric cancer cells while inhibiting apoptosis. Mechanistically, IGF2BP3 increases the expression of FBXO32 protein by binding to its mRNA and activates the cGMP-PKG signaling pathway, ultimately contributing to the progression of gastric cancer. The study suggests that targeting the IGF2BP3/FBXO32/cGMP-PKG axis could be a promising therapeutic approach for gastric cancer treatment. [Extracted from the article]

A recent report from investigators at the Cleveland Clinic discusses the use of endoscopic screening to detect signet ring cell gastric cancer (SRC) in patients with CDH1 pathogenic variants (PV) who are undergoing gastrectomy. The study found that SRCs were detected on gastrectomy specimens in 87.5% of patients who underwent gastrectomy, and SRCs were identified by endoscopy in 81% of these patients. The remaining patients who did not undergo gastrectomy and had no SRCs on random biopsies did not develop advanced diffuse gastric cancer (DGC) during the follow-up period. The researchers suggest that endoscopic surveillance may be a safe alternative to immediate prophylactic total gastrectomy in experienced hands in referral centers. [Extracted from the article]

A recent study conducted at Tangshan People's Hospital in Hebei, China, explored the diagnostic and prognostic significance of two biomarkers, CD44v9 and TIM3, in gastric cancer (GC) tissues. The study found that the expression of CD44v9 and TIM3 was significantly higher in tumor tissues compared to normal tissues. Additionally, high expression of CD44v9 in the CK- region of tumor tissues was associated with poor survival and independently predicted a poor prognosis in GC patients. The study suggests that dividing tissue regions based on CK expression is important for the diagnosis of GC, and TIM3 expression in the CK+ region shows diagnostic potential for GC. [Extracted from the article]

Researchers from Jining Medical University in Shandong, China have conducted a study on gastric cancer (GC) and its potential prognostic marker, gliomedin (GLDN). The study found that GLDN expression was positively correlated with advanced clinical stages of GC and was closely associated with poor prognosis in GC patients. Through experiments involving GLDN overexpression and knockdown in GC cell lines, as well as subcutaneous tumor formation in mice, the researchers demonstrated that GLDN promotes GC cell proliferation, viability, and migration. The study suggests that GLDN may regulate cell proliferation through the p53-p21-CyclinD/CDK4 signaling axis and proposes GLDN as a potential prognostic marker for GC patients. [Extracted from the article]

A new report from the University of California Davis School of Medicine provides fresh data on gastric cancer, specifically focusing on the genomic characteristics of gastric adenocarcinoma in Latino patients. The study found that Latinos have a higher risk of developing gastric cancer compared to non-Latino Whites, and that diffuse-type cancers, which are more prevalent in Latino patients, show increased treatment resistance. The research analyzed tumors from 237 Latino gastric adenocarcinoma patients, making it the largest cohort of Latino gastric cancer tumors sequenced to date. The study identified a higher proportion of genomically stable tumors in Latino patients compared to non-Latino patients, and highlighted the potential of targeting homologous recombination deficiency (HRD) as a treatment for both genomically stable and chromosomally unstable tumors. [Extracted from the article]

A recent report published by researchers in the Department of Surgical Oncology provides new insights into gastric cancer, specifically focusing on early-onset gastric cancer (EOGC) and conventional gastric cancer. EOGC, which accounts for approximately 10% of all gastric cancers, is known to be more aggressive and often diagnosed at an advanced stage, leading to a poor five-year survival rate. Risk factors for gastric cancer include family history, alcohol consumption, smoking, Helicobacter pylori infection, and Epstein-Barr virus infection. The study highlights the importance of genetic factors in EOGC and calls for further research in this area. [Extracted from the article]

A new report from Guangzhou University in Guangdong, China presents fresh data on gastric cancer segmentation in CT imaging. The researchers propose a new method called ALIEN (Attention-guided Cross-resolution Collaborative Network) that addresses the challenges of low contrast, blurry boundaries, and inter-individual variations in gastric cancer segmentation. The method integrates multiple modules to enhance the model's semantic awareness and achieve more accurate segmentation results. The research concludes that the proposed method outperforms current mainstream 3D segmentation networks and provides a publicly available code for further exploration. [Extracted from the article]

A recent study conducted at Seoul National University Hospital in South Korea explored the expression of Claudin 18.2 (CLDN18.2) in patients with stages II-IV gastric cancer (GC) or gastroesophageal junction (GEJ) adenocarcinoma. The researchers found that CLDN18.2 positivity was present in 34.4% of the patients and was more common in the middle and upper thirds of the stomach. The study also examined the correlation between CLDN18.2 expression and other biomarkers, such as PD-L1 and HER2. The findings of this study may contribute to future drug development and treatment options for GC patients. [Extracted from the article]

A recent study conducted at Sir Run Run Shaw Hospital explored the role of immunogenic cell death (ICD) in gastric cancer (GC). The researchers used single-cell sequencing analysis and machine learning to identify genes associated with ICD in GC. They developed a robust ICD-related gene signature and identified five key hub genes (SMAP2, TNFAIP8, LBH, TXNIP, and PIK3IP1) that were strongly correlated with immune microenvironment features. Of these genes, LBH was found to be particularly associated with a poor prognosis and the invasion and metastasis of GC. The findings were validated through immunohistochemical staining of a large clinical sample set, which further supported the role of LBH in promoting GC cell invasion through the activation of the epithelial-mesenchymal transition (EMT) pathway. [Extracted from the article]

A recent study conducted in Jiangxi, People's Republic of China, examined the risk predictors for 30-day unplanned readmissions following surgical treatment for gastric cancer. The study analyzed data from 12 studies involving 16,154 patients, with 1,736 patients being readmitted and 14,418 patients not being readmitted. The study found that several factors, including age, cardiovascular comorbidity, Nutritional Risk Screening (NRS) 2002 score, respiratory diseases, male sex, American Society of Anesthesiologists score, depth of invasion, discharge to home with care services, neoadjuvant therapy, post-operative complications, and blood transfusion, were associated with a higher likelihood of readmission. The researchers recommend providing extra attention and support to patients with these high-risk predictors during the perioperative period. [Extracted from the article]

A recent study conducted by researchers at the University of Science and Technology Beijing explores the heterogeneity of gastrointestinal cancer cells and its implications for personalized medicine. The researchers integrated and analyzed data from multiple modalities to gain a deeper understanding of the diversity of gastrointestinal cancer. By using a modified Canny algorithm to identify edges from tumor images and combining this with other data types, the study identified three distinct tumor subtypes and pinpointed hub genes associated with each subtype. This research enhances our understanding of gastrointestinal tumor heterogeneity and identifies potential biomarkers for personalized medicine and targeted treatments. [Extracted from the article]