1. Loss of 10q26.1-q26.3 in association with 7q34-q36.3 gain or 17q24.3-q25.3 gain predict poor outcome in pediatric medulloblastoma
- Author
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Gian Paolo Tonini, Eleonora Basso, Annalisa Pezzolo, Simona Aschero, Claudio Gambini, Paolo Nozza, Achille Iolascon, Armando Cama, Vito Pistoia, Maria Luisa Garrè, Valeria Capra, Federica Parodi, Alessandro Raso, Simona Coco, Angela Pistorio, Francesca Valdora, Giuseppe Cinalli, Massimo Zollo, Pezzolo, A, Coco, S, Raso, A, Parodi, F, Pistorio, A, Valdora, F, Capra, V, Zollo, Massimo, Aschero, S, Basso, E, Cama, A, Nozza, P, Gambini, C, Cinalli, G, Garrè, Ml, Iolascon, Achille, Pistoia, V, and Tonini, G. P.
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Multivariate analysis ,Adolescent ,Patient risk ,Treatment outcome ,Malignant brain tumor ,High resolution ,Loss of Heterozygosity ,Biology ,Bioinformatics ,Loss of heterozygosity ,Internal medicine ,medicine ,Biomarkers, Tumor ,Humans ,Child ,Medulloblastoma ,Comparative Genomic Hybridization ,Chromosomes, Human, Pair 10 ,Infant ,medicine.disease ,Prognosis ,Treatment Outcome ,Child, Preschool ,Multivariate Analysis ,Chromosomes, Human, Pair 7 ,Comparative genomic hybridization ,Chromosomes, Human, Pair 17 - Abstract
Medulloblastoma (MB) is the most common malignant brain tumor of childhood. We have investigated for novel chromosomal imbalances and prognostic markers of pediatric MB. Forty MBs out of 64, were analyzed using high resolution prometaphase comparative genomic hybridization. Chromosome 10q26.1-q26.3 loss combined with 17q24.3-q25.3 gain and/or 7q34-q36.3 gain in tumors predicted poor patient's survival. A minimal deleted region of 14.12cM at 10q26.1-q26.3 was refined by LOH analysis. We propose a new prognostic marker for pediatric MB patient risk stratification based on the presence of 10q26.1-q26.3 loss plus 17q24.3-q25.3 gain and/or 7q34-q36.3 gain associations.
- Published
- 2011