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Loss of 10q26.1-q26.3 in association with 7q34-q36.3 gain or 17q24.3-q25.3 gain predict poor outcome in pediatric medulloblastoma
- Source :
- Cancer letters. 308(2)
- Publication Year :
- 2011
-
Abstract
- Medulloblastoma (MB) is the most common malignant brain tumor of childhood. We have investigated for novel chromosomal imbalances and prognostic markers of pediatric MB. Forty MBs out of 64, were analyzed using high resolution prometaphase comparative genomic hybridization. Chromosome 10q26.1-q26.3 loss combined with 17q24.3-q25.3 gain and/or 7q34-q36.3 gain in tumors predicted poor patient's survival. A minimal deleted region of 14.12cM at 10q26.1-q26.3 was refined by LOH analysis. We propose a new prognostic marker for pediatric MB patient risk stratification based on the presence of 10q26.1-q26.3 loss plus 17q24.3-q25.3 gain and/or 7q34-q36.3 gain associations.
- Subjects :
- Oncology
Cancer Research
medicine.medical_specialty
Multivariate analysis
Adolescent
Patient risk
Treatment outcome
Malignant brain tumor
High resolution
Loss of Heterozygosity
Biology
Bioinformatics
Loss of heterozygosity
Internal medicine
medicine
Biomarkers, Tumor
Humans
Child
Medulloblastoma
Comparative Genomic Hybridization
Chromosomes, Human, Pair 10
Infant
medicine.disease
Prognosis
Treatment Outcome
Child, Preschool
Multivariate Analysis
Chromosomes, Human, Pair 7
Comparative genomic hybridization
Chromosomes, Human, Pair 17
Subjects
Details
- ISSN :
- 18727980
- Volume :
- 308
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Cancer letters
- Accession number :
- edsair.doi.dedup.....04de00f1417e0a78006b94be82f458db