1. The six-minute walk test in patients with AL amyloidosis: a single centre case series
- Author
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Vina Pulido, Gheorghe Doros, Vaishali Sanchorawala, and John L. Berk
- Subjects
Male ,medicine.medical_specialty ,New York Heart Association Class ,medicine.drug_class ,Walk Test ,030204 cardiovascular system & hematology ,03 medical and health sciences ,0302 clinical medicine ,Internal medicine ,medicine ,Natriuretic peptide ,AL amyloidosis ,Humans ,Aged ,Retrospective Studies ,Cardiopulmonary disease ,Exercise Tolerance ,business.industry ,Amyloidosis ,Hazard ratio ,Retrospective cohort study ,Hematology ,Middle Aged ,medicine.disease ,030220 oncology & carcinogenesis ,Heart failure ,Cardiology ,Female ,Cardiomyopathies ,business - Abstract
Summary The six-minute walk test (6MWT) has been widely used as an objective evaluation of functional exercise capacity and response to medical intervention in cardiopulmonary diseases. However, little is known about the 6MWT in evaluating patients with AL amyloidosis. We performed a retrospective study of 120 adults with systemic AL amyloidosis (60 with cardiac involvement and 60 without cardiac involvement) who had their initial evaluation at the Amyloidosis Center between 2013 and 2015 and had undergone 6MWT as a measure of functional exercise capacity. Forty-seven patients with cardiac involvement and 41 patients without cardiac involvement were included in the final analysis. The six-minute walk distances (6MWD) were 368 ± 105 m and 420 ± 116 m (mean ± SD), respectively (P = 0·03). Among AL amyloidosis patients with cardiac involvement, the 6MWD was associated with New York Heart Association class (P
- Published
- 2017