1. Comprehensive evaluation of the risk of lactational mastitis in Chinese women: combined logistic regression analysis with receiver operating characteristic curve
- Author
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Min Zhao, Xiao Guan, Yongshuo Yin, Zhiyong Yu, and Yuemei Wang
- Subjects
Adult ,0301 basic medicine ,Immunology & Inflammation ,China ,medicine.medical_specialty ,Breastfeeding ,Biophysics ,Mastitis ,Logistic regression ,Biochemistry ,Molecular Bases of Health & Disease ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Asian People ,law ,medicine ,Humans ,Lactation ,Logistic Regression ,030212 general & internal medicine ,Molecular Biology ,Diagnostics & Biomarkers ,Research Articles ,Retrospective Studies ,Pregnancy ,Univariate analysis ,030109 nutrition & dietetics ,Receiver operating characteristic ,business.industry ,Vaginal delivery ,Obstetrics ,Cell Biology ,Prognosis ,medicine.disease ,ROC curve ,Breast Feeding ,Logistic Models ,Risk factors ,Case-Control Studies ,Female ,Breast pump ,business - Abstract
Objective: To identify the potential risk factors for acute mastitis during lactation comprehensively. Subsequently, to evaluate logistic regression model in predicting the risk of lactational mastitis in Chinese women by applying receiver operating characteristic (ROC) curve. Methods: A case–control study among Chinese women enrolled 652 patients with mastitis and 581 healthy women with breastfeeding experience as control. The retrospective information was obtained by questionnaires that included medical history of pregnancy, delivery, puerperium and breastfeeding behaviors. Univariate analysis and multivariate logistic regression model were performed to investigate the relationship between these factors and the occurrence of lactational mastitis. Using ROC curve to evaluate the prognostic value of these selected indicators in the risk of acute mastitis. Results: The multivariate logistic regression analysis showed that the primiparity (P < 0.001), mastitis in previous breastfeeding (P < 0.001), nipple’s heteroplasia (P < 0.001), cracked nipple (P < 0.001), breast trauma by external force (P = 0.002), lateral position (P = 0.007), breast pump (P = 0.039), nipple sucking (P = 0.007), sleep with sucking (P = 0.007), and tongue-tie (P = 0.013) were risk variables independently and significantly related with mastitis. While vaginal delivery (P = 0.015), clean nipple before breastfeeding (P = 0.015), first contact with child within 1 h (P = 0.027) were protective factors. The ROC analysis demonstrated that the area under the curve of model 2 was 0.8122 (95%CI = 0.7885–0.8360), which stated that the model presented a high sensitivity and specificity. Conclusion: By means of collecting and summarizing the risk factors associated with the occurrence of breast mastitis in Chinese women, we established risk discriminant model to identify and warn the individuals susceptible to acute mastitis early, which will allow practitioners to provide appropriate management advice and effective individual care.
- Published
- 2020
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