1. Highly potent and selective Na
- Author
-
R Ian, Storer, Andy, Pike, Nigel A, Swain, Aristos J, Alexandrou, Bruce M, Bechle, David C, Blakemore, Alan D, Brown, Neil A, Castle, Matthew S, Corbett, Neil J, Flanagan, David, Fengas, M Scott, Johnson, Lyn H, Jones, Brian E, Marron, C Elizabeth, Payne, David, Printzenhoff, David J, Rawson, Colin R, Rose, Thomas, Ryckmans, Jianmin, Sun, Jonathan W, Theile, Rubben, Torella, Elaine, Tseng, and Joseph S, Warmus
- Subjects
Voltage-Gated Sodium Channel Blockers ,Sulfonamides ,Binding Sites ,Pyridines ,NAV1.7 Voltage-Gated Sodium Channel ,Pain ,Protein Structure, Tertiary ,Rats ,Molecular Docking Simulation ,Inhibitory Concentration 50 ,Mice ,Structure-Activity Relationship ,Dogs ,Piperidines ,Thiadiazoles ,Hepatocytes ,Microsomes, Liver ,Animals ,Humans ,Infusions, Intravenous ,Half-Life ,Protein Binding - Abstract
The discovery and selection of a highly potent and selective Na
- Published
- 2017