1. Neopetrosiquinones A and B, sesquiterpene benzoquinones isolated from the deep-water sponge Neopetrosia cf. proxima
- Author
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Esther A. Guzmán, John K. Reed, Amy E. Wright, Shirley A. Pomponi, Priscilla L. Winder, Patricia Linley, M. Cristina Diaz, and Heather L. Baker
- Subjects
food.ingredient ,Stereochemistry ,Clinical Biochemistry ,Pharmaceutical Science ,Sesquiterpene ,Biochemistry ,Neopetrosia ,Article ,chemistry.chemical_compound ,food ,Cell Line, Tumor ,Drug Discovery ,Benzoquinones ,Cytotoxic T cell ,Animals ,Humans ,Xestoquinone ,Molecular Biology ,IC50 ,biology ,Chemistry ,Organic Chemistry ,biology.organism_classification ,Porifera ,Sponge ,Cell culture ,Molecular Medicine ,Drug Screening Assays, Antitumor ,Petrosiidae ,Sesquiterpenes - Abstract
Two new marine-derived sesquiterpene benzoquinones which we designate as neopetrosiquinones A (1) and B (2), have been isolated from a deep-water sponge of the family Petrosiidae. The structures were elucidated on the basis of their spectroscopic data. Compounds 1 and 2 inhibit the in vitro proliferation of the DLD-1 human colorectal adenocarcinoma cell line with IC50 values of 3.7 and 9.8 μM, respectively, and the PANC-1 human pancreatic carcinoma cell line with IC50 values of 6.1 and 13.8 μM, respectively. Neopetrosiquinone A (1) also inhibited the in vitro proliferation of the AsPC-1 human pancreatic carcinoma cell line with an IC50 value of 6.1 μM. The compounds are structurally related to alisiaquinone A, cyclozonarone, and xestoquinone.
- Published
- 2011