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Neopetrosiquinones A and B, sesquiterpene benzoquinones isolated from the deep-water sponge Neopetrosia cf. proxima
- Source :
- Bioorganicmedicinal chemistry. 19(22)
- Publication Year :
- 2011
-
Abstract
- Two new marine-derived sesquiterpene benzoquinones which we designate as neopetrosiquinones A (1) and B (2), have been isolated from a deep-water sponge of the family Petrosiidae. The structures were elucidated on the basis of their spectroscopic data. Compounds 1 and 2 inhibit the in vitro proliferation of the DLD-1 human colorectal adenocarcinoma cell line with IC50 values of 3.7 and 9.8 μM, respectively, and the PANC-1 human pancreatic carcinoma cell line with IC50 values of 6.1 and 13.8 μM, respectively. Neopetrosiquinone A (1) also inhibited the in vitro proliferation of the AsPC-1 human pancreatic carcinoma cell line with an IC50 value of 6.1 μM. The compounds are structurally related to alisiaquinone A, cyclozonarone, and xestoquinone.
- Subjects :
- food.ingredient
Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
Sesquiterpene
Biochemistry
Neopetrosia
Article
chemistry.chemical_compound
food
Cell Line, Tumor
Drug Discovery
Benzoquinones
Cytotoxic T cell
Animals
Humans
Xestoquinone
Molecular Biology
IC50
biology
Chemistry
Organic Chemistry
biology.organism_classification
Porifera
Sponge
Cell culture
Molecular Medicine
Drug Screening Assays, Antitumor
Petrosiidae
Sesquiterpenes
Subjects
Details
- ISSN :
- 14643391
- Volume :
- 19
- Issue :
- 22
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry
- Accession number :
- edsair.doi.dedup.....7c114b551392689c7ff88dbde7ca1006