1. Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents.
- Author
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Zhang HW, Zhou L, Coats SJ, McBrayer TR, Tharnish PM, Bondada L, Detorio M, Amichai SA, Johns MD, Whitaker T, and Schinazi RF
- Subjects
- Animals, Antiviral Agents chemical synthesis, Cell Line, Cell Survival drug effects, Hepatitis C drug therapy, Humans, Purine Nucleosides chemical synthesis, Antiviral Agents chemistry, Antiviral Agents pharmacology, Hepacivirus drug effects, Purine Nucleosides chemistry, Purine Nucleosides pharmacology
- Abstract
Based on the anti-hepatitis C activity of 2'-C-methyl-adenosine and 2'-C-methyl-guanosine, a series of new modified purine 2'-C-methyl nucleosides was prepared as potential anti-hepatitis C virus agents. Herein, we report the synthesis of both 6-modified and 2-modified purine 2'-C-methyl-nucleosides along with their anti-HCV replication activity and cytotoxicity in different cells., (Published by Elsevier Ltd.)
- Published
- 2011
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