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Synthesis of purine modified 2'-C-methyl nucleosides as potential anti-HCV agents.
- Source :
-
Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2011 Nov 15; Vol. 21 (22), pp. 6788-92. Date of Electronic Publication: 2011 Sep 20. - Publication Year :
- 2011
-
Abstract
- Based on the anti-hepatitis C activity of 2'-C-methyl-adenosine and 2'-C-methyl-guanosine, a series of new modified purine 2'-C-methyl nucleosides was prepared as potential anti-hepatitis C virus agents. Herein, we report the synthesis of both 6-modified and 2-modified purine 2'-C-methyl-nucleosides along with their anti-HCV replication activity and cytotoxicity in different cells.<br /> (Published by Elsevier Ltd.)
- Subjects :
- Animals
Antiviral Agents chemical synthesis
Cell Line
Cell Survival drug effects
Hepatitis C drug therapy
Humans
Purine Nucleosides chemical synthesis
Antiviral Agents chemistry
Antiviral Agents pharmacology
Hepacivirus drug effects
Purine Nucleosides chemistry
Purine Nucleosides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1464-3405
- Volume :
- 21
- Issue :
- 22
- Database :
- MEDLINE
- Journal :
- Bioorganic & medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 21983447
- Full Text :
- https://doi.org/10.1016/j.bmcl.2011.09.034