1. Two new spirooxindole alkaloids from rhizosphere strain Streptomyces sp. xzqh-9.
- Author
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Guo, Kai, Fang, Tingting, Wang, Jingyi, Wu, An-an, Wang, Yuezhou, Jiang, Jie, Wu, Xinrui, Song, Siyang, Su, Wenjing, Xu, Qingyan, and Deng, Xianming
- Subjects
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OXINDOLE alkaloids , *RHIZOBACTERIA , *STREPTOMYCES , *SPECTRUM analysis , *COMPREHENSIVE examinations , *NUCLEAR magnetic resonance , *MASS spectrometry - Abstract
Two new spirooxindole alkaloids spindomycins A ( 1 ) and B ( 2 ) were isolated from rhizosphere strain Streptomyces sp . xzqh-9. Their structures were elucidated by comprehensive spectroscopic analyses of NMR and MS data. The absolute configurations of 1 and 2 were determined by experimental and theoretical calculation of electronic circular dichroism (ECD). Antitumor, lactate dehydrogenase, and tyrosine kinase inhibitory activities of two compounds were evaluated, while only spindomycin B ( 2 ) exhibited weak inhibitory activity against tyrosine kinase Bcr-Abl. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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