Back to Search
Start Over
Two new spirooxindole alkaloids from rhizosphere strain Streptomyces sp. xzqh-9.
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Nov2014, Vol. 24 Issue 21, p4995-4998. 4p. - Publication Year :
- 2014
-
Abstract
- Two new spirooxindole alkaloids spindomycins A ( 1 ) and B ( 2 ) were isolated from rhizosphere strain Streptomyces sp . xzqh-9. Their structures were elucidated by comprehensive spectroscopic analyses of NMR and MS data. The absolute configurations of 1 and 2 were determined by experimental and theoretical calculation of electronic circular dichroism (ECD). Antitumor, lactate dehydrogenase, and tyrosine kinase inhibitory activities of two compounds were evaluated, while only spindomycin B ( 2 ) exhibited weak inhibitory activity against tyrosine kinase Bcr-Abl. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 24
- Issue :
- 21
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 99066419
- Full Text :
- https://doi.org/10.1016/j.bmcl.2014.09.026