Search

Your search keyword '"Liu, Yan"' showing total 1 results

Refine your results

1 results on '"Liu, Yan"'

1. Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1).

Author

Nie, Zhe, Feher, Victoria, Natala, Srinivasa, McBride, Christopher, Kiryanov, Andre, Jones, Benjamin, Lam, Betty, Liu, Yan, Kaldor, Stephen, Stafford, Jeffrey, Hikami, Kouki, Uchiyama, Noriko, Kawamoto, Tomohiro, Hikichi, Yuichi, Matsumoto, Shin-ichi, Amano, Nobuyuki, Zhang, Lilly, Hosfield, David, Skene, Robert, and Zou, Hua

Subjects
*KINASE inhibitors, *ORAL medicine, *DRUG design, *DIAZEPINONES, *ANTINEOPLASTIC agents, *DRUG development
Abstract

Abstract: Using structure-based drug design, we identified and optimized a novel series of pyrimidodiazepinone PLK1 inhibitors resulting in the selection of the development candidate TAK-960. TAK-960 is currently undergoing Phase I evaluation in adult patients with advanced solid malignancies. [Copyright &y& Elsevier]

Published
2013
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results