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Discovery of TAK-960: An orally available small molecule inhibitor of polo-like kinase 1 (PLK1).
- Source :
-
Bioorganic & Medicinal Chemistry Letters . Jun2013, Vol. 23 Issue 12, p3662-3666. 5p. - Publication Year :
- 2013
-
Abstract
- Abstract: Using structure-based drug design, we identified and optimized a novel series of pyrimidodiazepinone PLK1 inhibitors resulting in the selection of the development candidate TAK-960. TAK-960 is currently undergoing Phase I evaluation in adult patients with advanced solid malignancies. [Copyright &y& Elsevier]
Details
- Language :
- English
- ISSN :
- 0960894X
- Volume :
- 23
- Issue :
- 12
- Database :
- Academic Search Index
- Journal :
- Bioorganic & Medicinal Chemistry Letters
- Publication Type :
- Academic Journal
- Accession number :
- 89103714
- Full Text :
- https://doi.org/10.1016/j.bmcl.2013.02.083