1. Interleukin receptor family member ST2 concentrations in patients following heart transplantation.
- Author
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Januzzi JL, Horne BD, Moore SA, Galenko O, Snow GL, Brunisholz KD, Muhlestein JB, Alharethi R, Carlquist JF, Budge D, Rasmussen K, and Kfoury AG
- Subjects
- Adult, Aged, Biomarkers blood, Female, Graft Rejection diagnosis, Graft Rejection mortality, Humans, Interleukin-1 Receptor-Like 1 Protein, Male, Middle Aged, Prognosis, Survival Analysis, Transplantation, Homologous, Graft Rejection blood, Heart Transplantation, Receptors, Cell Surface blood
- Abstract
Objective: To evaluate soluble (s) ST2 as a biomarker of rejection, allograft vasculopathy and mortality after orthotopic heart transplantation (OHT)., Methods: sST2 concentrations were measured in 241 patients following OHT., Results: Elevated sST2 was associated with cellular rejection (CR) ≥ 1R, with highest rates of CR in the 4th sST2 quartile (p = 0.003). No significant association between sST2 and antibody-mediated rejection or allograft vasculopathy was found. sST2 ≥ 30 ng/mL independently predicted death over 7-year follow-up (HR = 2.01; 95% CI 1.15-3.51; p = 0.01)., Conclusion: Concentrations of sST2 are associated with the presence of CR and predict long-term mortality following OHT.
- Published
- 2013
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