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Interleukin receptor family member ST2 concentrations in patients following heart transplantation.
- Source :
-
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2013 May; Vol. 18 (3), pp. 250-6. Date of Electronic Publication: 2013 Apr 05. - Publication Year :
- 2013
-
Abstract
- Objective: To evaluate soluble (s) ST2 as a biomarker of rejection, allograft vasculopathy and mortality after orthotopic heart transplantation (OHT).<br />Methods: sST2 concentrations were measured in 241 patients following OHT.<br />Results: Elevated sST2 was associated with cellular rejection (CR) ≥ 1R, with highest rates of CR in the 4th sST2 quartile (p = 0.003). No significant association between sST2 and antibody-mediated rejection or allograft vasculopathy was found. sST2 ≥ 30 ng/mL independently predicted death over 7-year follow-up (HR = 2.01; 95% CI 1.15-3.51; p = 0.01).<br />Conclusion: Concentrations of sST2 are associated with the presence of CR and predict long-term mortality following OHT.
Details
- Language :
- English
- ISSN :
- 1366-5804
- Volume :
- 18
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
- Publication Type :
- Academic Journal
- Accession number :
- 23557127
- Full Text :
- https://doi.org/10.3109/1354750X.2013.773081