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Start Over Descriptor "TNF-á inhibitors" Journal biological research
1 results on '"TNF-á inhibitors"'

1. Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion

Author

GLORIA D GALARCE, ROCÍO E FONCEA, ANA M EDWARDS, HERNÁN PESSOA-MAHANA, CARLOS D PESSOA-MAHANA, and ROBERTO A EBENSPERGER

Subjects
anti-inflammatory agents, benzimidazoquinazoline derivatives, TNF-á inhibitors, Biology (General), QH301-705.5
Abstract

This study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-á secretion in the human promyelocytic cell line HL-60. The compound 6-Phenyl-benzimidazo [1,2-c] quinazoline, coded as Gl, resulted as the most potent inhibitor and with no significant cytotoxic activity. Thus, 6-Arylbenzimidazo [1,2-c] quinazoline derivatives may have a potential as anti-inflammatory agents

Published
2008

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