Back to Search
Start Over
Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
- Source :
- Biological Research, Vol 41, Iss 1, Pp 43-50 (2008)
- Publication Year :
- 2008
- Publisher :
- BMC, 2008.
-
Abstract
- This study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-á secretion in the human promyelocytic cell line HL-60. The compound 6-Phenyl-benzimidazo [1,2-c] quinazoline, coded as Gl, resulted as the most potent inhibitor and with no significant cytotoxic activity. Thus, 6-Arylbenzimidazo [1,2-c] quinazoline derivatives may have a potential as anti-inflammatory agents
Details
- Language :
- English
- ISSN :
- 07169760 and 07176287
- Volume :
- 41
- Issue :
- 1
- Database :
- Directory of Open Access Journals
- Journal :
- Biological Research
- Publication Type :
- Academic Journal
- Accession number :
- edsdoj.53a531384e474277826538382d5b8c76
- Document Type :
- article