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1. Synthesis of Lipophilic Core-Shell Fe 3 O 4 @SiO 2 @Au Nanoparticles and Polymeric Entrapment into Nanomicelles: A Novel Nanosystem for in Vivo Active Targeting and Magnetic Resonance-Photoacoustic Dual Imaging.

Author

Monaco I, Arena F, Biffi S, Locatelli E, Bortot B, La Cava F, Marini GM, Severini GM, Terreno E, and Comes Franchini M

Subjects
Animals, Cell Proliferation drug effects, Female, Folic Acid chemistry, Humans, Image Processing, Computer-Assisted methods, Magnetite Nanoparticles chemistry, Mice, Mice, Inbred BALB C, Mice, Nude, Micelles, Multimodal Imaging methods, Ovarian Neoplasms metabolism, Tumor Cells, Cultured, Xenograft Model Antitumor Assays, Ferric Compounds chemistry, Gold chemistry, Magnetic Resonance Imaging methods, Magnetite Nanoparticles administration & dosage, Ovarian Neoplasms pathology, Photoacoustic Techniques methods, Polymers chemistry, Silicon Dioxide chemistry
Abstract

In this work, iron/silica/gold core-shell nanoparticles (Fe 3 O 4 @SiO 2 @Au NPs) characterized by magnetic and optical properties have been synthesized to obtain a promising theranostic platform. To improve their biocompatibility, the obtained multilayer nanoparticles have been entrapped in polymeric micelles, decorated with folic acid moieties, and tested in vivo for photoacoustic and magnetic resonance imaging detection of ovarian cancer.

Published
2017
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