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Synthesis of Lipophilic Core-Shell Fe 3 O 4 @SiO 2 @Au Nanoparticles and Polymeric Entrapment into Nanomicelles: A Novel Nanosystem for in Vivo Active Targeting and Magnetic Resonance-Photoacoustic Dual Imaging.
- Source :
-
Bioconjugate chemistry [Bioconjug Chem] 2017 May 17; Vol. 28 (5), pp. 1382-1390. Date of Electronic Publication: 2017 May 03. - Publication Year :
- 2017
-
Abstract
- In this work, iron/silica/gold core-shell nanoparticles (Fe <subscript>3</subscript> O <subscript>4</subscript> @SiO <subscript>2</subscript> @Au NPs) characterized by magnetic and optical properties have been synthesized to obtain a promising theranostic platform. To improve their biocompatibility, the obtained multilayer nanoparticles have been entrapped in polymeric micelles, decorated with folic acid moieties, and tested in vivo for photoacoustic and magnetic resonance imaging detection of ovarian cancer.
- Subjects :
- Animals
Cell Proliferation drug effects
Female
Folic Acid chemistry
Humans
Image Processing, Computer-Assisted methods
Magnetite Nanoparticles chemistry
Mice
Mice, Inbred BALB C
Mice, Nude
Micelles
Multimodal Imaging methods
Ovarian Neoplasms metabolism
Tumor Cells, Cultured
Xenograft Model Antitumor Assays
Ferric Compounds chemistry
Gold chemistry
Magnetic Resonance Imaging methods
Magnetite Nanoparticles administration & dosage
Ovarian Neoplasms pathology
Photoacoustic Techniques methods
Polymers chemistry
Silicon Dioxide chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1520-4812
- Volume :
- 28
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Bioconjugate chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 28453929
- Full Text :
- https://doi.org/10.1021/acs.bioconjchem.7b00076