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Your search keyword '"Zheng, Yi-Min"' showing total 3 results
Start Over Author "Zheng, Yi-Min" Journal biochemistry
3 results on '"Zheng, Yi-Min"'

1. Covalent linkage of prosthetic heme to CYP4 family P450 enzymes

Author

Henne, Kirk R., Kunze, Kent L., Zheng, Yi-Min, Christmas, Peter, Soberman, Roy J., and Rettie, allan E.

Subjects
Cytochrome P-450 -- Research, Heme -- Physiological aspects, Structure-activity relationships (Biochemistry) -- Analysis, Enzymes -- Structure-activity relationship, Biological sciences, Chemistry
Abstract

Research reveals that heme group is bound tightly at the active site of rabbit cytochrome P450-4B1 (CYP4B1) and base treatment of rabbit CYP4A human CYP4F subfamilies of heme-containing monooxygenases release a polar heme derivative. The general structural feature of mammalian CYP4 proteins may contain a covalently linked heme.

Published
2001

2. Covalent heme binding to CYP4B1 via Glu310 and a carbocation porphyrin intermediate

Author

Zheng, Yi-Min, Baer, Brian R., Kneller, M. Byron, Henne, Kirk R., Kunze, Kent L., and Rettie, Allan E.

Subjects
Biochemistry -- Research, Blood proteins -- Physiological aspects, Carrier proteins -- Genetic aspects, Carrier proteins -- Physiological aspects, Cations -- Genetic aspects, Carbon compounds -- Physiological aspects, Porphyrins -- Physiological aspects, Gene mutations -- Physiological aspects, Biological sciences, Chemistry
Abstract

Research has been conducted on CYP4B1. The authors report their investigation of the heme ester link site in CYP4B1, and their study of the functional consequences of the active site mutations.

Published
2003

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