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Start Over Author "Gabriel, Mark" Journal biochemistry
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1. Communication between the nucleotide binding domains of P-glycoprotein occurs via conformational changes that involve residue 508

Author

Gabriel, Mark P., Storm, Janet, Rothnie, Alice, Taylor, Andrew M., Linton, Kenneth J., Kerr, Ian D., and Callaghan, Richard

Subjects
Glycoproteins -- Research, Protein binding -- Analysis, Biological sciences, Chemistry
Abstract

Results suggest that the accessibility of residue 508 of alpha-helical subdomain of nucleotide binding domain 1 in P-glycoprotein alters due to ATP hydrolysis mediated confromational changes, thereby facilitating communication between the P-glycoprotein nucleotide binding domains as determined by cysteine-scanning mutagenesis.

Published
2003

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