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Communication between the nucleotide binding domains of P-glycoprotein occurs via conformational changes that involve residue 508
- Source :
- Biochemistry. July 1, 2003, Vol. 42 Issue 25, 7780-7789
- Publication Year :
- 2003
-
Abstract
- Results suggest that the accessibility of residue 508 of alpha-helical subdomain of nucleotide binding domain 1 in P-glycoprotein alters due to ATP hydrolysis mediated confromational changes, thereby facilitating communication between the P-glycoprotein nucleotide binding domains as determined by cysteine-scanning mutagenesis.
- Subjects :
- Glycoproteins -- Research
Protein binding -- Analysis
Biological sciences
Chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 00062960
- Volume :
- 42
- Issue :
- 25
- Database :
- Gale General OneFile
- Journal :
- Biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- edsgcl.105727936