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Start Over Author "Chess, David J." Journal biochemistry
2 results on '"Chess, David J."'

1. Succinyl-CoA synthetase is a phosphate target for the activation of mitochondrial metabolism

Author

Phillips, Darci, Aponte, Angel M., French, Stephanie A., Chess, David J., and Balaban, Robert S.

Subjects
Mitochondria -- Physiological aspects, Mitochondria -- Research, Ligases -- Physiological aspects, Ligases -- Research, Metabolism -- Research, Biological sciences, Chemistry
Abstract

The studies related to the enhanced enzymatic activity of inorganic phosphate ([P.sub.i]) that binds the porcine heart succinyl-CoA synthetase (SCS) [alpha]-subunit (SCS[alpha]) in a noncovalent manner which could provide a new target for [P.sub.i] activation in mitochondria is presented. The results provide insight into SCS activation by [P.sub.i] binding which represented another mitochondrial target for the [P.sub.i]-induced activation of oxidative phosphorylation and anaerobic ATP production in energy-limited mitochondria.

Published
2009

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