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6. The Prevalence and Risks of Inappropriate Combination of Aspirin and Warfarin in Clinical Practice: Results From WARFARIN-TR Study

Author

Salih Kılıç, Ahmet Çelik, Elif Çekirdekçi, Servet Altay, Deniz Elçik, Mehmet Kadri Akboğa, Mine Durukan, Çağrı Yayla, and Mehdi Zoghi

Subjects
Anticoagulants, antiplatelet drugs, aspirin, inappropriate prescribings, Warfarin, Medicine
Abstract

Background: The use of warfarin and aspirin in combination is restricted to limited patients under relevant guidelines. Aims: To evaluate the prevalence of the inappropriate combination of aspirin and warfarin therapy in daily practice and its risks. Study Design: Cross-sectional study. Methods: The awareness, efficacy, safety, and time in the therapeutic range of warfarin in the Turkish population study is a multi-center observational study that includes 4987 patients using warfarin for any reason between January 1, 2014, and December 31, 2014. To determine the prevalence of inappropriate combination use in daily practice, all patients who had a history of atherosclerotic disease (ischemic heart disease, peripheral artery disease) or cerebrovascular disease (n=1498) were excluded. The data of 3489 patients were analyzed. We defined inappropriate combination as all patients who received aspirin and warfarin regardless of the indication for warfarin use, under the direction of the European Society of Cardiology guideline recommendation. Results: The mean age of patients was 59.2±13.8 years (41.8% male). The prevalence of the inappropriate use of warfarin and aspirin combination was 20.0%. The prevalence of combination therapy in patients with a primary indication for mechanical heart valve, non-valvular atrial fibrillation, and other reasons was 20.5%, 18.7%, and 21.0%, respectively. Multivariate logistic regression analysis revealed that age (odds ratio, 1.009; 95% confidence interval, 1.002-1.015; p=0.010), heart failure (odds ratio, 1.765; 95% confidence interval, 1.448-2.151; p

Published
2019
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11. The Prevalence and Risks of Inappropriate Combination of Aspirin and Warfarin in Clinical Practice: Results From WARFARIN-TR Study

Author

Çağrı Yayla, Mine Durukan, Mehmet Kadri Akboga, Deniz Elcik, Elif Ijlal Cekirdekci, Ahmet Çelik, Servet Altay, Mehdi Zoghi, Salih Kilic, and Ege Üniversitesi

Subjects
medicine.medical_specialty, Temel Sağlık Hizmetleri, Combination therapy, lcsh:Medicine, 030204 cardiovascular system & hematology, Klinik Nöroloji, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Medicine, heterocyclic compounds, Inappropriate prescribings, cardiovascular diseases, 030212 general & internal medicine, Sağlık Bilimleri ve Hizmetleri, Genel ve Dahili Tıp, Cerrahi, Aspirin, business.industry, lcsh:R, ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS, Warfarin, Anticoagulants, Tıbbi Araştırmalar Deneysel, Atrial fibrillation, General Medicine, Odds ratio, Tıbbi İnformatik, medicine.disease, Thrombosis, Antiplatelet drugs, Confidence interval, ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS, ComputingMethodologies_PATTERNRECOGNITION, Original Article, InformationSystems_MISCELLANEOUS, business, Kidney disease, medicine.drug
Abstract

WOS: 000455438000004, PubMed ID: 30079702, Background: The use of warfarin and aspirin in combination is restricted to limited patients under relevant guidelines. Aims: To evaluate the prevalence of the inappropriate combination of aspirin and warfarin therapy in daily practice and its risks. Study Design: Cross-sectional study. Methods: The awareness, efficacy, safety, and time in the therapeutic range of warfarin in the Turkish population study is a multi-center observational study that includes 4987 patients using warfarin for any reason between January 1, 2014, and December 31, 2014. To determine the prevalence of inappropriate combination use in daily practice, all patients who had a history of atherosclerotic disease (ischemic heart disease, peripheral artery disease) or cerebrovascular disease (n=1498) were excluded. The data of 3489 patients were analyzed. We defined inappropriate combination as all patients who received aspirin and warfarin regardless of the indication for warfarin use, under the direction of the European Society of Cardiology guideline recommendation. Results: The mean age of patients was 59.2 +/- 13.8 years (41.8% male). The prevalence of the inappropriate use of warfarin and aspirin combination was 20.0%. The prevalence of combination therapy in patients with a primary indication for mechanical heart valve, non-valvular atrial fibrillation, and other reasons was 20.5%, 18.7%, and 21.0%, respectively. Multivariate logistic regression analysis revealed that age (odds ratio, 1.009; 95% confidence interval, 1.002-1.015; p=0.010), heart failure (odds ratio, 1.765; 95% confidence interval, 1.448-2.151; p

Published
2019

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