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The Prevalence and Risks of Inappropriate Combination of Aspirin and Warfarin in Clinical Practice: Results From WARFARIN-TR Study
- Source :
- Balkan Medical Journal, Balkan Medical Journal, Vol 36, Iss 1, Pp 17-22 (2019)
- Publication Year :
- 2019
- Publisher :
- AVES Publishing Co., 2019.
-
Abstract
- WOS: 000455438000004<br />PubMed ID: 30079702<br />Background: The use of warfarin and aspirin in combination is restricted to limited patients under relevant guidelines. Aims: To evaluate the prevalence of the inappropriate combination of aspirin and warfarin therapy in daily practice and its risks. Study Design: Cross-sectional study. Methods: The awareness, efficacy, safety, and time in the therapeutic range of warfarin in the Turkish population study is a multi-center observational study that includes 4987 patients using warfarin for any reason between January 1, 2014, and December 31, 2014. To determine the prevalence of inappropriate combination use in daily practice, all patients who had a history of atherosclerotic disease (ischemic heart disease, peripheral artery disease) or cerebrovascular disease (n=1498) were excluded. The data of 3489 patients were analyzed. We defined inappropriate combination as all patients who received aspirin and warfarin regardless of the indication for warfarin use, under the direction of the European Society of Cardiology guideline recommendation. Results: The mean age of patients was 59.2 +/- 13.8 years (41.8% male). The prevalence of the inappropriate use of warfarin and aspirin combination was 20.0%. The prevalence of combination therapy in patients with a primary indication for mechanical heart valve, non-valvular atrial fibrillation, and other reasons was 20.5%, 18.7%, and 21.0%, respectively. Multivariate logistic regression analysis revealed that age (odds ratio, 1.009; 95% confidence interval, 1.002-1.015; p=0.010), heart failure (odds ratio, 1.765; 95% confidence interval, 1.448-2.151; p
- Subjects :
- medicine.medical_specialty
Temel Sağlık Hizmetleri
Combination therapy
lcsh:Medicine
030204 cardiovascular system & hematology
Klinik Nöroloji
03 medical and health sciences
0302 clinical medicine
Internal medicine
Medicine
heterocyclic compounds
Inappropriate prescribings
cardiovascular diseases
030212 general & internal medicine
Sağlık Bilimleri ve Hizmetleri
Genel ve Dahili Tıp
Cerrahi
Aspirin
business.industry
lcsh:R
ComputerSystemsOrganization_COMPUTER-COMMUNICATIONNETWORKS
Warfarin
Anticoagulants
Tıbbi Araştırmalar Deneysel
Atrial fibrillation
General Medicine
Odds ratio
Tıbbi İnformatik
medicine.disease
Thrombosis
Antiplatelet drugs
Confidence interval
ComputingMilieux_MANAGEMENTOFCOMPUTINGANDINFORMATIONSYSTEMS
ComputingMethodologies_PATTERNRECOGNITION
Original Article
InformationSystems_MISCELLANEOUS
business
Kidney disease
medicine.drug
Subjects
Details
- ISSN :
- 21463131, 21463123, and 00045543
- Database :
- OpenAIRE
- Journal :
- Balkan Medical Journal
- Accession number :
- edsair.doi.dedup.....c7eb4a753c72fc47ccf29cc86450acad