1. Association between loss of bone mass due to short sleep and leptin-sympathetic nervous system activity
- Author
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Kanae Hashiguchi, Nagato Kuriyama, Masao Kurokawa, Teruhide Koyama, Shinsuke Yamada, Shigeto Mizuno, Chie Omichi, Koichi Iwasa, Fumitoshi Niwa, Rika Tanaka, Daisuke Matsui, Yutaro Yoneda, Etsuko Ozaki, Masaaki Inaba, Yoshiyuki Watanabe, Motoyuki Horii, Isao Watanabe, and Komei Iwai
- Subjects
Leptin ,Male ,Sleep Wake Disorders ,Nervous system ,Aging ,medicine.medical_specialty ,Sympathetic nervous system ,Health (social science) ,030209 endocrinology & metabolism ,Bone resorption ,Bone remodeling ,03 medical and health sciences ,0302 clinical medicine ,Bone Density ,Heart Rate ,Internal medicine ,Cortical Bone ,medicine ,Humans ,Heart rate variability ,Tartrate-Resistant Acid Phosphatase ,business.industry ,Middle Aged ,Alkaline Phosphatase ,Endocrinology ,medicine.anatomical_structure ,Female ,Cortical bone ,Geriatrics and Gerontology ,business ,Gerontology ,Cancellous bone ,Biomarkers ,030217 neurology & neurosurgery ,Densitometry - Abstract
Background Sleep has been reported to be an important factor in bone metabolism, and sympathetic nervous system activity has been reported to regulate bone metabolism. In this study, we evaluated the association between sleep, sympathetic nervous system activity, and bone mass. Methods The study subjects were 221 individuals (108 males; 113 females; mean age: 55.1 ± 7.0 years) divided into two groups: those who slept for less than 6 h a day (short sleep [SS] group), and those who slept 6 h or longer (normal sleep [NS] group). The groups were compared with regard to lifestyle, cortical bone thickness, cancellous bone density, bone metabolism markers, blood leptin levels, and sympathetic nervous system activity as evaluated by heart rate variability analysis. Results Significant differences were observed between the two groups in cortical bone thickness, blood TRACP-5b, and leptin levels. The L/H ratio (an index of sympathetic nervous system activity) was higher in the SS group than in the NS group. Significant negative correlations were observed between cortical bone thickness and both the L/H ratio and leptin levels, and a significant positive correlation was observed between the L/H ratio and leptin levels. Conclusions Short sleep was associated with a decline in cortical bone thickness due to the promotion of bone resorption and sympathetic nervous system hyperactivity in the middle-aged group. Leptin levels and cortical bone thickness were found to be closely related, suggesting that cortical bone mass may be regulated via interaction with the leptin-sympathetic nervous system.
- Published
- 2017