Back to Search
Start Over
Association between loss of bone mass due to short sleep and leptin-sympathetic nervous system activity
- Source :
- Archives of Gerontology and Geriatrics. 70:201-208
- Publication Year :
- 2017
- Publisher :
- Elsevier BV, 2017.
-
Abstract
- Background Sleep has been reported to be an important factor in bone metabolism, and sympathetic nervous system activity has been reported to regulate bone metabolism. In this study, we evaluated the association between sleep, sympathetic nervous system activity, and bone mass. Methods The study subjects were 221 individuals (108 males; 113 females; mean age: 55.1 ± 7.0 years) divided into two groups: those who slept for less than 6 h a day (short sleep [SS] group), and those who slept 6 h or longer (normal sleep [NS] group). The groups were compared with regard to lifestyle, cortical bone thickness, cancellous bone density, bone metabolism markers, blood leptin levels, and sympathetic nervous system activity as evaluated by heart rate variability analysis. Results Significant differences were observed between the two groups in cortical bone thickness, blood TRACP-5b, and leptin levels. The L/H ratio (an index of sympathetic nervous system activity) was higher in the SS group than in the NS group. Significant negative correlations were observed between cortical bone thickness and both the L/H ratio and leptin levels, and a significant positive correlation was observed between the L/H ratio and leptin levels. Conclusions Short sleep was associated with a decline in cortical bone thickness due to the promotion of bone resorption and sympathetic nervous system hyperactivity in the middle-aged group. Leptin levels and cortical bone thickness were found to be closely related, suggesting that cortical bone mass may be regulated via interaction with the leptin-sympathetic nervous system.
- Subjects :
- Leptin
Male
Sleep Wake Disorders
Nervous system
Aging
medicine.medical_specialty
Sympathetic nervous system
Health (social science)
030209 endocrinology & metabolism
Bone resorption
Bone remodeling
03 medical and health sciences
0302 clinical medicine
Bone Density
Heart Rate
Internal medicine
Cortical Bone
medicine
Humans
Heart rate variability
Tartrate-Resistant Acid Phosphatase
business.industry
Middle Aged
Alkaline Phosphatase
Endocrinology
medicine.anatomical_structure
Female
Cortical bone
Geriatrics and Gerontology
business
Gerontology
Cancellous bone
Biomarkers
030217 neurology & neurosurgery
Densitometry
Subjects
Details
- ISSN :
- 01674943
- Volume :
- 70
- Database :
- OpenAIRE
- Journal :
- Archives of Gerontology and Geriatrics
- Accession number :
- edsair.doi.dedup.....8a22c0f5f0374334617de24955aa4227