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Start Over Author "Mónica Cacho" Journal antimicrobial agents and chemotherapy
1 results on '"Mónica Cacho"'

1. Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection

Author

Dereje A. Negatu, Rubén González del Río, Mónica Cacho-Izquierdo, David Barros-Aguirre, Joël Lelievre, Joaquín Rullas, Patricia Casado, Uday S. Ganapathy, Matthew D. Zimmerman, Martin Gengenbacher, Véronique Dartois, and Thomas Dick

Subjects
Pharmacology, Infectious Diseases, Pharmacology (medical)
Abstract

The combination of the β-lactam tebipenem and the β-lactamase inhibitor avibactam shows potent bactericidal activity against Mycobacterium abscessus in vitro . Here, we report that the combination of the respective oral prodrugs tebipenem-pivoxil and avibactam ARX-1796 showed efficacy in a mouse model of M. abscessus lung infection.

Published
2023
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