Activity of Oral Tebipenem-Avibactam in a Mouse Model of Mycobacterium abscessus Lung Infection

Authors :: Dereje A. Negatu
Rubén González del Río
Mónica Cacho-Izquierdo
David Barros-Aguirre
Joël Lelievre
Joaquín Rullas
Patricia Casado
Uday S. Ganapathy
Matthew D. Zimmerman
Martin Gengenbacher
Véronique Dartois
Thomas Dick
Source :: Antimicrobial Agents and Chemotherapy. 67
Publication Year :: 2023
Publisher :: American Society for Microbiology, 2023.
Abstract: The combination of the β-lactam tebipenem and the β-lactamase inhibitor avibactam shows potent bactericidal activity against Mycobacterium abscessus in vitro . Here, we report that the combination of the respective oral prodrugs tebipenem-pivoxil and avibactam ARX-1796 showed efficacy in a mouse model of M. abscessus lung infection.

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