1. Ultrashort Antimicrobial Peptides with Antiendotoxin Properties.
- Author
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Chih YH, Lin YS, Yip BS, Wei HJ, Chu HL, Yu HY, Cheng HT, Chou YT, and Cheng JW
- Subjects
- Antimicrobial Cationic Peptides chemistry, Hydrophobic and Hydrophilic Interactions, Microbial Sensitivity Tests, beta-Alanine analogs & derivatives, beta-Alanine chemistry, Anti-Bacterial Agents pharmacology, Antimicrobial Cationic Peptides pharmacology, Gram-Negative Bacteria drug effects, Lipopolysaccharides antagonists & inhibitors
- Abstract
Release of lipopolysaccharide (LPS) (endotoxin) from bacteria into the bloodstream may cause serious unwanted stimulation of the host immune system. Some but not all antimicrobial peptides can neutralize LPS-stimulated proinflammatory responses. Salt resistance and serum stability of short antimicrobial peptides can be boosted by adding β-naphthylalanine to their termini. Herein, significant antiendotoxin effects were observed in vitro and in vivo with the β-naphthylalanine end-tagged variants of the short antimicrobial peptides S1 and KWWK., (Copyright © 2015, American Society for Microbiology. All Rights Reserved.)
- Published
- 2015
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