Back to Search
Start Over
Boosting salt resistance of short antimicrobial peptides.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2013 Aug; Vol. 57 (8), pp. 4050-2. Date of Electronic Publication: 2013 May 28. - Publication Year :
- 2013
-
Abstract
- The efficacies of many antimicrobial peptides are greatly reduced under high salt concentrations, therefore limiting their use as pharmaceutical agents. Here, we describe a strategy to boost salt resistance and serum stability of short antimicrobial peptides by adding the nonnatural bulky amino acid β-naphthylalanine to their termini. The activities of the short salt-sensitive tryptophan-rich peptide S1 were diminished at high salt concentrations, whereas the activities of its β-naphthylalanine end-tagged variants were less affected.
- Subjects :
- Amino Acid Sequence
Ampicillin chemistry
Anti-Infective Agents chemistry
Drug Stability
Erythrocytes drug effects
Escherichia coli drug effects
Hemolysis
Humans
Microbial Sensitivity Tests
Peptides chemistry
Serum chemistry
Tryptophan chemistry
beta-Alanine chemistry
Ampicillin pharmacology
Anti-Infective Agents pharmacology
Peptides pharmacology
Sodium Chloride chemistry
beta-Alanine analogs & derivatives
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 57
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 23716061
- Full Text :
- https://doi.org/10.1128/AAC.00252-13