1. Interspecies analysis of the chemopreventive efficacy of dietary alpha-difluoromethylornithine.
- Author
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Ratko TA, Detrisac CJ, Rao KV, Thomas CF, Kelloff GJ, and Moon RC
- Subjects
- Animals, Cricetinae, Diet, Eflornithine therapeutic use, Female, Mammary Neoplasms, Experimental prevention & control, Mesocricetus, Mice, Mice, Inbred Strains, Rats, Rats, Inbred Strains, Species Specificity, Tracheal Neoplasms prevention & control, Urinary Bladder Neoplasms prevention & control, Eflornithine administration & dosage, Neoplasms, Experimental prevention & control
- Abstract
The anticarcinogenic efficacy of the polyamine biosynthesis inhibitor, alpha-difluoromethylornithine (DFMO), was assessed in three rodent models of human epithelial cancer. In DMBA-induced female, Sprague-Dawley rats, DMFO treatment (3.2 or 6.4 g/kg diet) for 180 days significantly inhibited mammary carcinogenesis and reduced tumor-related intercurrent mortality compared to untreated controls. In male, C57BL/6x DBA/2F1 mice induced with N-butyl-N(4-hydroxybutyl)nitrosamine (OH-BBN), DFMO treatment (2 or 4 g/kg diet) concurrent with the period of carcinogen administration significantly reduced the incidence and severity of urinary bladder carcinomas. In methylnitrosourea (MNU)-induced male Syrian golden hamsters, DFMO (3.2 g/kg diet) numerically reduced the incidence and size of tracheal carcinoma relative to untreated controls. DFMO-mediated toxicity was not evident in any of the animals on study, although a slight reduction in mean body weight gain was evident in rats and mice.
- Published
- 1990