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Interspecies analysis of the chemopreventive efficacy of dietary alpha-difluoromethylornithine.

Interspecies analysis of the chemopreventive efficacy of dietary alpha-difluoromethylornithine.

Authors :
Ratko TA
Detrisac CJ
Rao KV
Thomas CF
Kelloff GJ
Moon RC
Source :
Anticancer research [Anticancer Res] 1990 Jan-Feb; Vol. 10 (1), pp. 67-72.
Publication Year :
1990

Abstract

The anticarcinogenic efficacy of the polyamine biosynthesis inhibitor, alpha-difluoromethylornithine (DFMO), was assessed in three rodent models of human epithelial cancer. In DMBA-induced female, Sprague-Dawley rats, DMFO treatment (3.2 or 6.4 g/kg diet) for 180 days significantly inhibited mammary carcinogenesis and reduced tumor-related intercurrent mortality compared to untreated controls. In male, C57BL/6x DBA/2F1 mice induced with N-butyl-N(4-hydroxybutyl)nitrosamine (OH-BBN), DFMO treatment (2 or 4 g/kg diet) concurrent with the period of carcinogen administration significantly reduced the incidence and severity of urinary bladder carcinomas. In methylnitrosourea (MNU)-induced male Syrian golden hamsters, DFMO (3.2 g/kg diet) numerically reduced the incidence and size of tracheal carcinoma relative to untreated controls. DFMO-mediated toxicity was not evident in any of the animals on study, although a slight reduction in mean body weight gain was evident in rats and mice.

Details

Language :
English
ISSN :
0250-7005
Volume :
10
Issue :
1
Database :
MEDLINE
Journal :
Anticancer research
Publication Type :
Academic Journal
Accession number :
2110434