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Interspecies analysis of the chemopreventive efficacy of dietary alpha-difluoromethylornithine.
Interspecies analysis of the chemopreventive efficacy of dietary alpha-difluoromethylornithine.
- Source :
-
Anticancer research [Anticancer Res] 1990 Jan-Feb; Vol. 10 (1), pp. 67-72. - Publication Year :
- 1990
-
Abstract
- The anticarcinogenic efficacy of the polyamine biosynthesis inhibitor, alpha-difluoromethylornithine (DFMO), was assessed in three rodent models of human epithelial cancer. In DMBA-induced female, Sprague-Dawley rats, DMFO treatment (3.2 or 6.4 g/kg diet) for 180 days significantly inhibited mammary carcinogenesis and reduced tumor-related intercurrent mortality compared to untreated controls. In male, C57BL/6x DBA/2F1 mice induced with N-butyl-N(4-hydroxybutyl)nitrosamine (OH-BBN), DFMO treatment (2 or 4 g/kg diet) concurrent with the period of carcinogen administration significantly reduced the incidence and severity of urinary bladder carcinomas. In methylnitrosourea (MNU)-induced male Syrian golden hamsters, DFMO (3.2 g/kg diet) numerically reduced the incidence and size of tracheal carcinoma relative to untreated controls. DFMO-mediated toxicity was not evident in any of the animals on study, although a slight reduction in mean body weight gain was evident in rats and mice.
- Subjects :
- Animals
Cricetinae
Diet
Eflornithine therapeutic use
Female
Mammary Neoplasms, Experimental prevention & control
Mesocricetus
Mice
Mice, Inbred Strains
Rats
Rats, Inbred Strains
Species Specificity
Tracheal Neoplasms prevention & control
Urinary Bladder Neoplasms prevention & control
Eflornithine administration & dosage
Neoplasms, Experimental prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 0250-7005
- Volume :
- 10
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 2110434