1. Principles of unconventional myosin function and targeting.
- Author
-
Hartman MA, Finan D, Sivaramakrishnan S, and Spudich JA
- Subjects
- Actins ultrastructure, Animals, Calcium metabolism, Cell Adhesion, Cell Movement, Cytoskeleton metabolism, Cytoskeleton ultrastructure, GTP Phosphohydrolases metabolism, Humans, Membrane Lipids chemistry, Membrane Lipids metabolism, Membrane Microdomains chemistry, Membrane Microdomains metabolism, Microfilament Proteins metabolism, Molecular Motor Proteins ultrastructure, Myosins ultrastructure, Protein Isoforms ultrastructure, Protein Processing, Post-Translational, Actins metabolism, Molecular Motor Proteins metabolism, Myosins metabolism, Protein Isoforms metabolism
- Abstract
Unconventional myosins are a superfamily of actin-based motors implicated in diverse cellular processes. In recent years, much progress has been made in describing their biophysical properties, and headway has been made into analyzing their cellular functions. Here, we focus on the principles that guide in vivo motor function and targeting to specific cellular locations. Rather than describe each motor comprehensively, we outline the major themes that emerge from research across the superfamily and use specific examples to illustrate each. In presenting the data in this format, we seek to identify open questions in each field as well as to point out commonalities between them. To advance our understanding of myosins' roles in vivo, clearly we must identify their cellular cargoes and the protein complexes that regulate motor attachment to fully appreciate their functions on the cellular and developmental levels.
- Published
- 2011
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