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Principles of unconventional myosin function and targeting.
- Source :
-
Annual review of cell and developmental biology [Annu Rev Cell Dev Biol] 2011; Vol. 27, pp. 133-55. Date of Electronic Publication: 2011 May 31. - Publication Year :
- 2011
-
Abstract
- Unconventional myosins are a superfamily of actin-based motors implicated in diverse cellular processes. In recent years, much progress has been made in describing their biophysical properties, and headway has been made into analyzing their cellular functions. Here, we focus on the principles that guide in vivo motor function and targeting to specific cellular locations. Rather than describe each motor comprehensively, we outline the major themes that emerge from research across the superfamily and use specific examples to illustrate each. In presenting the data in this format, we seek to identify open questions in each field as well as to point out commonalities between them. To advance our understanding of myosins' roles in vivo, clearly we must identify their cellular cargoes and the protein complexes that regulate motor attachment to fully appreciate their functions on the cellular and developmental levels.
- Subjects :
- Actins ultrastructure
Animals
Calcium metabolism
Cell Adhesion
Cell Movement
Cytoskeleton metabolism
Cytoskeleton ultrastructure
GTP Phosphohydrolases metabolism
Humans
Membrane Lipids chemistry
Membrane Lipids metabolism
Membrane Microdomains chemistry
Membrane Microdomains metabolism
Microfilament Proteins metabolism
Molecular Motor Proteins ultrastructure
Myosins ultrastructure
Protein Isoforms ultrastructure
Protein Processing, Post-Translational
Actins metabolism
Molecular Motor Proteins metabolism
Myosins metabolism
Protein Isoforms metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1530-8995
- Volume :
- 27
- Database :
- MEDLINE
- Journal :
- Annual review of cell and developmental biology
- Publication Type :
- Academic Journal
- Accession number :
- 21639800
- Full Text :
- https://doi.org/10.1146/annurev-cellbio-100809-151502