1. Progressive White Matter Injury in Preclinical Dutch Cerebral Amyloid Angiopathy.
- Author
-
Shirzadi Z, Yau WW, Schultz SA, Schultz AP, Scott MR, Goubran M, Mojiri-Forooshani P, Joseph-Mathurin N, Kantarci K, Preboske G, Wermer MJH, Jack C, Benzinger T, Taddei K, Sohrabi HR, Sperling RA, Johnson KA, Bateman RJ, Martins RN, Greenberg SM, and Chhatwal JP
- Subjects
- Cerebral Hemorrhage diagnostic imaging, Cerebral Hemorrhage pathology, Cross-Sectional Studies, Hemorrhage pathology, Humans, Magnetic Resonance Imaging, Neuroimaging, Cerebral Amyloid Angiopathy diagnostic imaging, Cerebral Amyloid Angiopathy pathology, White Matter diagnostic imaging, White Matter pathology
- Abstract
Autosomal-dominant, Dutch-type cerebral amyloid angiopathy (D-CAA) offers a unique opportunity to develop biomarkers for pre-symptomatic cerebral amyloid angiopathy (CAA). We hypothesized that neuroimaging measures of white matter injury would be present and progressive in D-CAA prior to hemorrhagic lesions or symptomatic hemorrhage. In a longitudinal cohort of D-CAA carriers and non-carriers, we observed divergence of white matter injury measures between D-CAA carriers and non-carriers prior to the appearance of cerebral microbleeds and >14 years before the average age of first symptomatic hemorrhage. These results indicate that white matter disruption measures may be valuable cross-sectional and longitudinal biomarkers of D-CAA progression. ANN NEUROL 2022;92:358-363., (© 2022 American Neurological Association.)
- Published
- 2022
- Full Text
- View/download PDF