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Progressive White Matter Injury in Preclinical Dutch Cerebral Amyloid Angiopathy.
- Source :
-
Annals of neurology [Ann Neurol] 2022 Sep; Vol. 92 (3), pp. 358-363. Date of Electronic Publication: 2022 Jun 25. - Publication Year :
- 2022
-
Abstract
- Autosomal-dominant, Dutch-type cerebral amyloid angiopathy (D-CAA) offers a unique opportunity to develop biomarkers for pre-symptomatic cerebral amyloid angiopathy (CAA). We hypothesized that neuroimaging measures of white matter injury would be present and progressive in D-CAA prior to hemorrhagic lesions or symptomatic hemorrhage. In a longitudinal cohort of D-CAA carriers and non-carriers, we observed divergence of white matter injury measures between D-CAA carriers and non-carriers prior to the appearance of cerebral microbleeds and >14 years before the average age of first symptomatic hemorrhage. These results indicate that white matter disruption measures may be valuable cross-sectional and longitudinal biomarkers of D-CAA progression. ANN NEUROL 2022;92:358-363.<br /> (© 2022 American Neurological Association.)
- Subjects :
- Cerebral Hemorrhage diagnostic imaging
Cerebral Hemorrhage pathology
Cross-Sectional Studies
Hemorrhage pathology
Humans
Magnetic Resonance Imaging
Neuroimaging
Cerebral Amyloid Angiopathy diagnostic imaging
Cerebral Amyloid Angiopathy pathology
White Matter diagnostic imaging
White Matter pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1531-8249
- Volume :
- 92
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Annals of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 35670654
- Full Text :
- https://doi.org/10.1002/ana.26429