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Your search keyword '"Yin, Xia"' showing total 12 results
Start Over Author "Yin, Xia" Journal angewandte chemie international edition
12 results on '"Yin, Xia"'

5. Assessing the Progression of Early Atherosclerosis Mice Using a Fluorescence Nanosensor for the Simultaneous Detection and Imaging of pH and Phosphorylation.

Author

Li, Jin, Zhao, Na, Zhang, Wei, Li, Ping, Yin, Xia, Zhang, Wen, Wang, Hui, and Tang, Bo

Subjects
FLUORESCENCE, ATHEROSCLEROTIC plaque, ATHEROSCLEROSIS, PHOSPHORYLATION, VASCULAR endothelium
Abstract

The inflammatory microenvironment involves changes in pH and protein phosphorylation state and is closely related to the occurrence and development of atherosclerosis (AS). Herein, we constructed a dual‐detection fluorescence nanosensor PCN‐NP‐HPZ based on post modification of MOFs, which realized the simultaneous detection and imaging of pH and phosphorylation through the pH‐sensitive group piperazine and the ZrIV node of the MOFs. The sensors were used to monitor changes in blood pH and phosphate levels at different time stages during atherosclerotic plaque formation. Two‐photon fluorescence imaging was also performed in the vascular endothelium. Blood tests combined with two‐photon fluorescence images indicated that in the early stage of AS, blood and tissue pH levels were lower than that of the normal mice, while phosphate and tissue phosphorylation levels were higher than that of the normal mice. The present study provides a new analysis method for the assessment of early atherosclerotic disease. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Enantioselective Nickel‐Catalyzed C(sp3)−H Activation of Formamides.

Author

Wang, Yin‐Xia, Zhang, Feng‐Ping, Chen, Hao, Li, Yue, Li, Jiang‐Fei, and Ye, Mengchun

Subjects
*PHOSPHINE oxides, *BIMETALLIC catalysts, *LAMINATED metals, *HETEROCYCLIC compounds, *PHOSPHINE
Abstract

Enantioselective Ni‐catalyzed C(sp3)−H bond activation remains an elusive challenge. Herein, we used phosphine oxide‐ligated Ni−Al bimetallic catalyst to realize enantioselective Ni‐catalyzed aliphatic C(sp3)−H activation of formamides, providing a series of chiral N‐containing heterocycles in 40–95 % yield and 70–95 % ee. [ABSTRACT FROM AUTHOR]

Published
2022
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10. Ligand-Accelerated Direct C−H Arylation of BINOL: A Rapid One-Step Synthesis of Racemic 3,3′-Diaryl BINOLs

Author

Wei-Wei Yao, Rong-Hua Wang, Mengchun Ye, Qi-Sheng Liu, Yin-Xia Wang, and Jin-Fei Yang

Subjects
chemistry, 010405 organic chemistry, Ligand, Organic chemistry, chemistry.chemical_element, One-Step, General Medicine, General Chemistry, 010402 general chemistry, 01 natural sciences, Catalysis, 0104 chemical sciences, Rhodium
Abstract

An ortho-selective rhodium-catalyzed direct C-H arylation of 1,1'-bi-2-naphthol (BINOL), to deliver the widely used but not easily available 3,3'-diaryl BINOL, has been developed. This highly efficient one-step synthetic approach is the shortest route to date and is greatly facilitated by the newly developed ligand system comprising tBu2 PCl, Ph2 -cod, and Cy3 P⋅HBF4 . In addition, the same procedure can facilitate the challenging syntheses of 3-bulkyaryl BINOLs in good to excellent yields.

Published
2016

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