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Your search keyword '"Zhong YL"' showing total 15 results
Start Over Author "Zhong YL" Journal angewandte chemie international ed in english
15 results on '"Zhong YL"'

1. A polar radical pair pathway to assemble the pyrimidinone core of the HIV integrase inhibitor raltegravir potassium.

Author

Pye PJ, Zhong YL, Jones GO, Reamer RA, Houk KN, and Askin D

Subjects
HIV Integrase Inhibitors chemistry, Organic Chemicals chemistry, Potassium chemistry, Pyrimidinones chemistry, Pyrrolidinones, Raltegravir Potassium, HIV Integrase Inhibitors chemical synthesis, Organic Chemicals chemical synthesis, Pyrimidinones chemical synthesis
Published
2008
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2. Rapid Access to Complex Molecular Architectures via o-Azaquinones We thank Dr. D. H. Huang, G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. This work was supported financially by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (P.S.B), and grants from ArrayBiopharma, Pfizer, Glaxo, Merck, Schering Plough, Hoffmann-La Roche, Boehringer Ingelheim, DuPont, and Abbott Laboratories.

Author

Nicolaou KC, Zhong YL, Baran PS, and Sugita K

Published
2001

3. Rapid Access to Complex Molecular Architectures via o-Azaquinones.

Author

Nicolaou KC, Zhong YL, Baran PS, and Sugita K

Abstract

A multitude of natural product like molecules such as 2 and 3 can be readily obtained from hydroxyketoamide 1. The versatile 1 is derived, via the intermediate o-azaquinone 4, from the Dess-Martin periodinane oxidation of the corresponding anilide., (© 2001 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.)

Published
2001
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4. New Synthetic Technology for the Construction of N-Containing Quinones and Derivatives Thereof: Total Synthesis of Epoxyquinomycin B We thank Dr. D. H. Huang, Dr. G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (P.B.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.

Author

Nicolaou KC, Sugita K, Baran PS, and Zhong YL

Published
2001

5. Mechanistic Studies of Periodinane-Mediated Reactions of Anilides and Related Systems Professors M. G. Finn, A. Eschenmoser, and M. E. Newcomb are gratefully acknowledged for valuable discussions and suggestions. We thank Dr. D. H. Huang and Dr. G. Siuzdak for NMR spectroscopic and mass spectrometric assistance, respectively. We would also like to thank Dr. G. Vasilikogiannakis for helpful discussions and an anonymous referee for critical suggestions. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (P.B.), postdoctoral fellowships from ArrayBiopharma (N.Z.) and Bayer AG (R.K.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.

Author

Nicolaou KC, Baran PS, Kranich R, Zhong YL, Sugita K, and Zou N

Published
2001

8. New Synthetic Technology for the Construction of N-Containing Quinones and Derivatives Thereof: Total Synthesis of Epoxyquinomycin B We thank Dr. D. H. Huang, Dr. G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively. Financial support for this work was provided by The Skaggs Institute for Chemical Biology, the National Institutes of Health (USA), a predoctoral fellowship from the National Science Foundation (P.B.), and grants from Abbott, Amgen, ArrayBiopharma, Boehringer-Ingelheim, Glaxo, Hoffmann-LaRoche, DuPont, Merck, Novartis, Pfizer, and Schering Plough.

Author

Nicolaou KC, Sugita K, Baran PS, and Zhong YL

Published
2001

9. Novel IBX-Mediated Processes for the Synthesis of Amino Sugars and Libraries Thereof We thank Dr. D. H. Huang, Dr. G. Siuzdak, and Dr. R. Chadha for NMR spectroscopic, mass spectrometric, and X-ray crystallographic assistance, respectively, and Prof. H. M. R. Hoffmann and Prof. A. Eschenmoser for helpful discussions. We also thank Dr. Maria-Rosa Rodriguez and Mr. Keith Wilcoxen of these laboratories for early intermediates leading to 9-12. This work was financially supported by the National Institutes of Health (USA), The Skaggs Institute for Chemical Biology, fellowships from the Ministerio de Educacion y Cultura, Spain (J.A.V.) and the National Science Foundation (P.S.B), and grants from Array Biopharma, Pfizer, GlaxoWellcome, Merck, Schering Plough, Hoffmann-LaRoche, Boehringer Ingelheim, DuPont, and Abbott Laboratories.

Author

Nicolaou KC, Baran PS, Zhong YL, and Vega JA

Published
2000

10. The Absolute Configuration and Asymmetric Total Synthesis of the CP Molecules (CP-263,114 and CP-225,917, Phomoidrides B and A) We thank Drs. D. H. Huang, G. Siuzdak, and R. Chadha for assistance with NMR spectroscopy, mass spectrometry, and X-ray crystallography, respectively. This work was financially supported by the National Institutes of Health (USA), The Skaggs Institute for Chemical Biology, doctoral fellowships from the National Science Foundation (P.S.B.) and Boehringer Ingelheim (Y.H.), and grants from Array Biopharma, Boehringer Ingelheim, Schering Plough, Pfizer, Glaxo, Merck, Hoffmann-La Roche, DuPont, and Abbott Laboratories.

Author

Nicolaou KC, Jung JK, Yoon WH, He Y, Zhong YL, and Baran PS

Published
2000
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11. New Synthetic Technology for the Rapid Construction of Novel Heterocycles-Part 1: The Reaction of Dess - Martin Periodinane with Anilides and Related Compounds.

Author

Nicolaou KC, Zhong YL, and Baran PS

Abstract

The unusual behavior of hypervalent iodine reagents, Dess - Martin periodinane and IBX, with an array of anilides leads to the formation of complex heterocycles in only one synthetic operation (see scheme). Furthermore, the substrates for these transformations are available in one step from readily available commercial building blocks. The mechanism by which these periodinanes interact with anilides is also explored. This exciting new class of chemical reactions was discovered during the course of the total synthesis of the CP molecules and leads to compounds which are relevant to chemical biology investigations and pharmaceutical research.

Published
2000

12. New Synthetic Technology for the Rapid Construction of Novel Heterocycles-Part 2. The Reaction of IBX with Anilides and Related Compounds.

Author

Nicolaou KC, Zhong YL, and Baran PS

Abstract

The unusual behavior of hypervalent iodine reagents, Dess - Martin periodinane and IBX, with an array of anilides leads to the formation of complex heterocycles in only one synthetic operation (see scheme). Furthermore, the substrates for these transformations are available in one step from readily available commercial building blocks. The mechanism by which these periodinanes interact with anilides is also explored. This exciting new class of chemical reactions was discovered during the course of the total synthesis of the CP molecules and leads to compounds which are relevant to chemical biology investigations and pharmaceutical research.

Published
2000
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15. A Novel Route to the Fused Maleic Anhydride Moiety of CP Molecules.

Author

Nicolaou KC, Baran PS, Jautelat R, He Y, Fong KC, Choi HS, Yoon WH, and Zhong YL

Abstract

A seven-step cascade reaction-in which selective mesylation, epoxide formation, epoxide lysis, cyclization, reiterative oxidation, and nitrogen-oxygen exchange occur sequentially-facilitates the construction of the maleic anhydride moiety of CP molecules 1 and 2 (>93% yield per step). Unstable intermediates of this reaction sequence were detected, providing evidence for the proposed mechanism and resulting in the discovery of a new chemical entity., (© 1999 WILEY-VCH Verlag GmbH, Weinheim, Fed. Rep. of Germany.)

Published
1999
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