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Formation of C-C bonds from CO2 is a much sought after reaction in organic synthesis. To date, other than C-H carboxylations using stoichiometric amounts of metals, base, or organometallic reagents, little is known about C-C bond formation. In fact, to the best of our knowledge no catalytic methylation of C-H bonds using CO2 and H2 has been reported. Described herein is the combination of CO2 and H2 for efficient methylation of carbon nucleophiles such as indoles, pyrroles, and electron-rich arenes. Comparison experiments which employ paraformaldehyde show similar reactivity for the CO2/H2 system. [ABSTRACT FROM AUTHOR]

Formation of C-C bonds from CO2 is a much sought after reaction in organic synthesis. To date, other than C-H carboxylations using stoichiometric amounts of metals, base, or organometallic reagents, little is known about C-C bond formation. In fact, to the best of our knowledge no catalytic methylation of C-H bonds using CO2 and H2 has been reported. Described herein is the combination of CO2 and H2 for efficient methylation of carbon nucleophiles such as indoles, pyrroles, and electron-rich arenes. Comparison experiments which employ paraformaldehyde show similar reactivity for the CO2/H2 system. [ABSTRACT FROM AUTHOR]

The authors focus on the methylation of amines with carbon dioxide and hydrogen molecule (H2). They mention that two catalysts formed from ruthenium acetylacetonate [Ru(acac)3] and 1,1,1-tris(diphenylphosphinomethyl) ethane, enabled the conversion of carbon dioxide and carboxylic acid derivatives into N,N-dimethylaniline and N-methylaniline. They mention that methylation reaction with formamide and methanol formed intermediates, which then reduced to a methylated product.

The authors focus on the methylation of amines with carbon dioxide and hydrogen molecule (H2). They mention that two catalysts formed from ruthenium acetylacetonate [Ru(acac)3] and 1,1,1-tris(diphenylphosphinomethyl) ethane, enabled the conversion of carbon dioxide and carboxylic acid derivatives into N,N-dimethylaniline and N-methylaniline. They mention that methylation reaction with formamide and methanol formed intermediates, which then reduced to a methylated product.