1. Biamperometric Determination of Tetracycline in Pharmaceuticals
- Author
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Renato S. Lima, Everaldo Paulo de Medeiros, Glimaldo Marino, Valberes B. Nascimento, Mário César Ugulino de Araújo, Francisco Fernandes Gambarra Neto, and Wellington da Silva Lyra
- Subjects
Detection limit ,Chromatography ,Tetracycline ,Supporting electrolyte ,Chemistry ,Biochemistry (medical) ,Clinical Biochemistry ,Relative standard deviation ,Biochemistry ,Analytical Chemistry ,Tetracycline Hydrochloride ,Sequential method ,Reagent ,Electrochemistry ,medicine ,Spectroscopy ,medicine.drug - Abstract
A fast, reliable, and low cost biamperometric flow‐injection method, with an error of 1.3% and an analytical throughput of 55 samples h−1, for determination of tetracycline hydrochloride in pharmaceuticals capsules is proposed. The analytical curve was linear (r=0.998) in the range 10 to 50 mg l−1 using Fe(CN)6 3− and NaOH solutions as reagent and carrier stream/supporting electrolyte, respectively. A relative standard deviation of 1.6% (10 sequential injections of 30.0 mg l−1) was verified with detection and quantification limits of 0.6 and 3.4 mg l−1, respectively.
- Published
- 2007
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