1. Induction of Colonic M Cells during Intestinal Inflammation.
- Author
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Bennett KM, Parnell EA, Sanscartier C, Parks S, Chen G, Nair MG, and Lo DD
- Subjects
- Animals, CX3C Chemokine Receptor 1, Citrobacter rodentium, Colon pathology, Colon ultrastructure, Cytokines metabolism, Dextran Sulfate toxicity, Disease Models, Animal, Enterobacteriaceae Infections physiopathology, Epithelial Cells ultrastructure, Humans, Intestinal Mucosa pathology, Intestinal Mucosa ultrastructure, Irritants toxicity, Mice, Inbred BALB C, Mice, Inbred C57BL, Mice, Transgenic, Microscopy, Electron, Scanning, Microvilli pathology, Microvilli ultrastructure, Peyer's Patches, Receptors, Chemokine metabolism, Tumor Necrosis Factor-alpha antagonists & inhibitors, Colitis pathology, Epithelial Cells pathology
- Abstract
Intestinal M (microfold) cells are specialized epithelial cells overlying lymphoid tissues in the small intestine. Unlike common enterocytes, M cells lack an organized apical brush border, and are able to transcytose microparticles across the mucosal barrier to underlying antigen-presenting cells. We found that in both the dextran sodium sulfate and Citrobacter rodentium models of colitis, significantly increased numbers of Peyer's patch (PP) phenotype M cells were induced at the peak of inflammation in colonic epithelium, often accompanied by loosely organized lamina propria infiltrates. PP type M cells are thought to be dependent on cytokines, including tumor necrosis factor (TNF)-α and receptor activator of nuclear factor kappa-B ligand; these cytokines were also found to be induced in the inflamed tissues. The induction of M cells was abrogated by anti-TNF-α blockade, suggesting that anti-TNF-α therapies may have similar effects in clinical settings, although the functional consequences are not clear. Our results suggest that inflammatory cytokine-induced PP type M cells may be a useful correlate of chronic intestinal inflammation., (Copyright © 2016 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.)
- Published
- 2016
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