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Induction of Colonic M Cells during Intestinal Inflammation.
- Source :
-
The American journal of pathology [Am J Pathol] 2016 May; Vol. 186 (5), pp. 1166-79. Date of Electronic Publication: 2016 Mar 03. - Publication Year :
- 2016
-
Abstract
- Intestinal M (microfold) cells are specialized epithelial cells overlying lymphoid tissues in the small intestine. Unlike common enterocytes, M cells lack an organized apical brush border, and are able to transcytose microparticles across the mucosal barrier to underlying antigen-presenting cells. We found that in both the dextran sodium sulfate and Citrobacter rodentium models of colitis, significantly increased numbers of Peyer's patch (PP) phenotype M cells were induced at the peak of inflammation in colonic epithelium, often accompanied by loosely organized lamina propria infiltrates. PP type M cells are thought to be dependent on cytokines, including tumor necrosis factor (TNF)-α and receptor activator of nuclear factor kappa-B ligand; these cytokines were also found to be induced in the inflamed tissues. The induction of M cells was abrogated by anti-TNF-α blockade, suggesting that anti-TNF-α therapies may have similar effects in clinical settings, although the functional consequences are not clear. Our results suggest that inflammatory cytokine-induced PP type M cells may be a useful correlate of chronic intestinal inflammation.<br /> (Copyright © 2016 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
CX3C Chemokine Receptor 1
Citrobacter rodentium
Colon pathology
Colon ultrastructure
Cytokines metabolism
Dextran Sulfate toxicity
Disease Models, Animal
Enterobacteriaceae Infections physiopathology
Epithelial Cells ultrastructure
Humans
Intestinal Mucosa pathology
Intestinal Mucosa ultrastructure
Irritants toxicity
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Transgenic
Microscopy, Electron, Scanning
Microvilli pathology
Microvilli ultrastructure
Peyer's Patches
Receptors, Chemokine metabolism
Tumor Necrosis Factor-alpha antagonists & inhibitors
Colitis pathology
Epithelial Cells pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1525-2191
- Volume :
- 186
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The American journal of pathology
- Publication Type :
- Academic Journal
- Accession number :
- 26948422
- Full Text :
- https://doi.org/10.1016/j.ajpath.2015.12.015